Adults: The dosage and duration of therapy should be established depending on type and severity of infection, and the condition of the patient.
Recommended Daily Dosage: 500 mg IV every 8 hrs in the treatment of pneumonia, urinary tract infections, gynaecological infections eg, endometritis, skin and skin structure infections.
One (1) g IV every 8 hrs in the treatment of nosocomial pneumonias, peritonitis, presumed infections in neutropenic patients and septicaemia.
In meningitis, the recommended dosage is 2 g every 8 hrs.
As with other antibiotics, particular caution is recommended in using meropenem as monotherapy in critically ill patients with known or suspected Pseudomonas aeruginosa lower respiratory tract infection.
Regular sensitivity testing is recommended when treating Pseudomonas aeruginosa infection.
Renal Impairment: Dosage should be reduced in patients with creatinine clearance <51 mL/min, as scheduled in Table 2. (See Table 2.)
Click on icon to see table/diagram/image
Meropenem is cleared by haemodialysis. If continued treatment with Meronem is necessary, it is recommended that the unit dose (based on the type and severity of infection) is administered at the completion of the haemodialysis procedure to restore therapeutically effective plasma concentrations.
There is no experience with the use of Meronem in patients under peritoneal dialysis.
Hepatic Insufficiency: No dosage adjustment is necessary in patients with hepatic insufficiency (see Precautions).
Children: For children >3 months and up to 12 years, the IV recommended dose is 10-20 mg/kg every 8 hrs depending on type and severity of infection, susceptibility of the pathogen, and the condition of the patient. In children >50 kg weight, adult dosage should be used.
In meningitis, the recommended dose is 40 mg/kg every 8 hrs.
There is no experience in children with renal impairment.
Elderly: No dosage adjustment is required for the elderly with normal renal function or creatinine clearance values >50 mL/min.
Administration: Meronem can be given as an IV bolus injection over approximately 5 min or by IV infusion over approximately 15-30 min.
Meronem, to be used for bolus IV injection, should be constituted with sterile water for injections (meropenem 5 mL/250 mg). This provides an approximate concentration of 50 mg/mL. Constituted solutions are clear and colourless or pale yellow.
Meronem for IV infusion may be constituted with compatible infusion fluids (50-200 mL). (See Interactions.)