Administer at time 0 (time of oxazaphosphorine administration), after 4 hr & after 8 hr, w/ each dose being 20% of the oxazaphosphorine dose. High dose cytotoxic therapy
Total dose may be increased up to 120% of the oxazaphosphorine dose. Continuous infusions of ifosfamide
Mesna bolus inj (20% of the ifosfamide dose) at time 0 (start of infusion), & add mesna to the continuous infusion at a dose of up to 100% of the ifosfamide dose. To maintain uroprotection after the end of ifosfamide infusion, give mesna dose equivalent to up to 50% of the ifosfamide dose for further 6-12 hr. Childn
Administer more frequently (eg, 6 times) at shorter intervals (eg, 3 hr).