Metformin Stella

Metformin Stella

metformin

Manufacturer:

Stellapharm

Distributor:

HK Medical Supplies
/
Health Express
Concise Prescribing Info
Contents
Metformin HCl
Indications/Uses
As monotherapy or in combination w/ other antidiabetic agents or insulin for treatment of type 2 DM, particularly in overwt patients, when dietary management & exercise alone does not result in adequate glycaemic control.
Dosage/Direction for Use
Adult w/ normal renal function Monotherapy & combination w/ other oral antidiabetic agents Initially 500 mg bd or tds. Adjust dose after 10-15 days based on blood glucose measurements. Max dose: 3 g daily, in 3 divided doses. Combination w/ insulin Initially 500 mg bd or tds, while insulin dose is adjusted based on blood glucose measurements. Renal impairment GFR 60-89 mL/min Max dose: 3 g daily divided into 2-3 daily doses, GFR 45-59 mL/min Max dose: 2 g daily divided into 2-3 daily doses, GFR 30-44 mL/min Max dose: 1 g daily divided into 2-3 daily doses. Childn & adolescent ≥10 yr Monotherapy or combination w/ insulin Initially 500 mg once daily. Adjust dose after 10-15 days based on blood glucose measurements. Max dose: 2 g daily, in 2 or 3 divided doses.
Administration
Should be taken with food.
Contraindications
Hypersensitivity. Acute metabolic acidosis (eg, lactic acidosis, diabetic ketoacidosis). Diabetic pre-coma. Severe renal failure (GFR <30 mL/min). Acute conditions w/ potential to alter renal function eg, dehydration, severe infection, shock. Disease which may cause tissue hypoxia (especially acute disease, or worsening of disease) eg, decompensated heart failure, resp failure, recent MI, shock. Hepatic insufficiency, acute alcohol intoxication, alcoholism.
Special Precautions
Lactic acidosis. Increased risk of hypoxia & renal insufficiency in patients w/ heart failure. Assess GFR before treatment initiation & regularly thereafter. Discontinue metformin at the time of surgery under general, spinal or epidural anaesth; may be restarted after 48 hr following surgery or resumption of oral nutrition. All patients should continue their diet w/ a regular distribution of carbohydrate intake during the day. Overwt patients should continue their energy-restricted diet. Concomitant use w/ insulin or other oral antidiabetics. Intravascular administration of iodinated contrast agents. Pregnancy & lactation. Elderly.
Drug Interactions
Increased risk of lactic acidosis w/ alcohol, iodinated contrast agents, NSAIDs (including COX II inhibitors), ACE inhibitors, angiotensin II receptor antagonists, loop diuretics. Potential interaction w/ medicinal products w/ intrinsic hyperglycaemic activity eg, glucorticoids & sympathomimetics. Reduced efficacy w/ OCT1 inhibitors (eg, verapamil). Increased GI absorption & efficacy w/ OCT1 inducers (eg, rifampicin). Decreased renal elimination & increased plasma conc w/ OCT2 inhibitors (eg, cimetidine, dolutegravir, ranolazine, trimethoprim, vandetanib, isavuconazole). Altered efficacy & renal elimination w/ both OCT1 & OCT2 inhibitors (eg, crizotinib, olaparib).
MIMS Class
ATC Classification
A10BA02 - metformin ; Belongs to the class of biguanides. Used in the treatment of diabetes.
Presentation/Packing
Form
Metformin Stella FC tab 500 mg
Packing/Price
30's
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