Metoprolol Krka

Metoprolol Krka





Hind Wing
Agencia Lei Va Hong
Concise Prescribing Info
Metoprolol succinate
Treatment of HTN; angina pectoris; arrhythmia; stable heart failure w/ symptoms (eg, shortness of breath or swollen ankles), when taken together w/ other medicines for heart failure; palpitations due to functional heart disorders. Prevention of further heart attacks or damage to the heart after a heart attack; migraine.
Dosage/Direction for Use
Adult HTN 50 mg once daily, may be increased to 100-200 mg once daily if necessary. Angina pectoris 100-200 mg once daily. Arrhythmia 100-200 mg once daily. Palpitations due to heart disease 100 mg once daily, may be increased to 200 mg once daily if necessary. Preventive therapy following a heart attack 200 mg once daily. Prevention of migraine 100-200 mg once daily.
Hypersensitivity to metoprolol or to other β-blockers. Heart conduction problems (2nd or 3rd degree AV block) or heart rhythm problems (sick sinus syndrome); untreated heart failure, concomitantly receiving treatment to increase heart contractions, shock caused by heart problems; severe peripheral arterial disease; slow heart rate (<50 beats/min) or low BP; metabolic acidosis; severe asthma or COPD; untreated phaeochromocytoma; heart failure & BP keeps falling <100 mmHg. Concomitant use w/ MAOIs; verapamil, diltiazem; antiarrhythmics eg, disopyramide.
Special Precautions
Patients w/ asthma; Prinzmetal's angina; DM; phaeochromocytoma; overactive thyroid; psoriasis; blood circulation problems which may cause fingers & toes to tingle or turn pale or blue; heart conduction disorder (heart block); severe liver impairment. Patients being treated for allergic reactions. Patients w/ heart failure & 1 of the following: unstable heart failure (NYHA IV), recent heart attack or angina attack in the last 28 days; reduced kidney or liver function; age <40 yr or >80 yr; diseases of the heart valves; enlarged heart muscle; previous heart surgery in the last 4 mth. Concomitant anaesth. May affect ability to drive & use machines. Not recommended during pregnancy or breastfeeding.
Adverse Reactions
Feeling faint on standing due to low BP; tiredness. Slow heartbeat; difficulty in maintaining balance (very rarely w/ fainting); cold hands & feet; palpitations; dizziness, headache; feeling sick, diarrhoea, constipation, abdominal pain; shortness of breath w/ strenuous physical activity.
Drug Interactions
Increased BP-lowering effect w/ MAOIs; other BP-lowering medicines eg, verapamil & diltiazem. Increased risk of irregular or slow heart beat & reduced heart function w/ antiarrhythmics eg, disopyramide. Increased BP-lowering effect w/ cimetidine; hydralazine, clonidine; terbinafine; paroxetine, fluoxetine, sertraline; hydroxychloroquine; chlorpromazine, triflupromazine, chlorprothixene; amiodarone, quinidine, propafenone; diphenhydramine; celecoxib; alcohol. Reduced BP-lowering effect w/ indomethacin, rifampicin. Potential interaction w/ other β-blockers eg, eye drops; adrenaline (epinephrine), noradrenaline (norepinephrine) or other sympathomimetics; antidiabetics; lidocaine; reserpine, α-methyldopa, guanfacine, cardiac glycosides.
MIMS Class
ATC Classification
C07AB02 - metoprolol ; Belongs to the class of selective beta-blocking agents. Used in the treatment of cardiovascular diseases.
Metoprolol Krka PR tab 25 mg
Metoprolol Krka PR tab 50 mg
Metoprolol Krka PR tab 100 mg
Metoprolol Krka PR tab 200 mg
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