Metoprolol Krka

Metoprolol Krka

metoprolol

Manufacturer:

Krka

Distributor:

Hind Wing
/
Agencia Lei Va Hong
Concise Prescribing Info
Contents
Metoprolol succinate
Indications/Uses
Treatment of HTN; angina pectoris; arrhythmia; stable heart failure w/ symptoms (eg, shortness of breath or swollen ankles), when taken together w/ other medicines for heart failure; palpitations due to functional heart disorders. Prevention of further heart attacks or damage to the heart after a heart attack; migraine.
Dosage/Direction for Use
Adult HTN 50 mg once daily, may be increased to 100-200 mg once daily if necessary. Angina pectoris 100-200 mg once daily. Arrhythmia 100-200 mg once daily. Palpitations due to heart disease 100 mg once daily, may be increased to 200 mg once daily if necessary. Preventive therapy following a heart attack 200 mg once daily. Prevention of migraine 100-200 mg once daily.
Contraindications
Hypersensitivity to metoprolol or to other β-blockers. Heart conduction problems (2nd or 3rd degree AV block) or heart rhythm problems (sick sinus syndrome); untreated heart failure, concomitantly receiving treatment to increase heart contractions, shock caused by heart problems; severe peripheral arterial disease; slow heart rate (<50 beats/min) or low BP; metabolic acidosis; severe asthma or COPD; untreated phaeochromocytoma; heart failure & BP keeps falling <100 mmHg. Concomitant use w/ MAOIs; verapamil, diltiazem; antiarrhythmics eg, disopyramide.
Special Precautions
Patients w/ asthma; Prinzmetal's angina; DM; phaeochromocytoma; overactive thyroid; psoriasis; blood circulation problems which may cause fingers & toes to tingle or turn pale or blue; heart conduction disorder (heart block); severe liver impairment. Patients being treated for allergic reactions. Patients w/ heart failure & 1 of the following: unstable heart failure (NYHA IV), recent heart attack or angina attack in the last 28 days; reduced kidney or liver function; age <40 yr or >80 yr; diseases of the heart valves; enlarged heart muscle; previous heart surgery in the last 4 mth. Concomitant anaesth. May affect ability to drive & use machines. Not recommended during pregnancy or breastfeeding.
Adverse Reactions
Feeling faint on standing due to low BP; tiredness. Slow heartbeat; difficulty in maintaining balance (very rarely w/ fainting); cold hands & feet; palpitations; dizziness, headache; feeling sick, diarrhoea, constipation, abdominal pain; shortness of breath w/ strenuous physical activity.
Drug Interactions
Increased BP-lowering effect w/ MAOIs; other BP-lowering medicines eg, verapamil & diltiazem. Increased risk of irregular or slow heart beat & reduced heart function w/ antiarrhythmics eg, disopyramide. Increased BP-lowering effect w/ cimetidine; hydralazine, clonidine; terbinafine; paroxetine, fluoxetine, sertraline; hydroxychloroquine; chlorpromazine, triflupromazine, chlorprothixene; amiodarone, quinidine, propafenone; diphenhydramine; celecoxib; alcohol. Reduced BP-lowering effect w/ indomethacin, rifampicin. Potential interaction w/ other β-blockers eg, eye drops; adrenaline (epinephrine), noradrenaline (norepinephrine) or other sympathomimetics; antidiabetics; lidocaine; reserpine, α-methyldopa, guanfacine, cardiac glycosides.
MIMS Class
Beta-Blockers
ATC Classification
C07AB02 - metoprolol ; Belongs to the class of selective beta-blocking agents. Used in the treatment of cardiovascular diseases.
Presentation/Packing
Form
Metoprolol Krka PR tab 25 mg
Packing/Price
100's
Form
Metoprolol Krka PR tab 50 mg
Packing/Price
100's
Form
Metoprolol Krka PR tab 100 mg
Packing/Price
100's
Form
Metoprolol Krka PR tab 200 mg
Packing/Price
100's
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