Renovascular HTN; intravascular hypovolaemia; dual blockade of renin-angiotensin-aldosterone system (RAAS); other conditions w/ RAAS stimulation; primary aldosteronism; aortic or mitral valve stenosis, or obstructive hypertrophic cardiomyopathy; metabolic & endocrine effects; electrolyte imbalance (eg, hypokalaemia, hyperkalaemia, hyponatraemia & hypochloraemic alkalosis, hypercalcaemia, hypomagnesaemia); acute myopia & angle-closure glaucoma; non-melanoma skin cancer. Risk of MI or stroke in case of excessive BP reduction in patients w/ ischaemic cardiopathy or ischaemic CV disease. Reports of exacerbation or activation of SLE w/ thiazide diuretics. Intolerance to sorbitol & lactose monohydrate. Hypersensitivity & photosensitivity reactions. Caution in patients w/ impaired hepatic function; renal impairment & kidney transplantation. Not recommended during the 1st trimester of pregnancy. Ethnic differences. Childn <18 yr.