Motilium

Motilium

domperidone

Manufacturer:

Janssen

Distributor:

DCH Auriga - Healthcare
/
Four Star
Concise Prescribing Info
Contents
Domperidone
Indications/Uses
Symptomatic relief of nausea & vomiting.
Dosage/Direction for Use
Adult & adolescent ≥12 yr & weighing ≥35 kg 1 tab up to tds. Max: 30 mg/day.
Administration
Should be taken on an empty stomach: Take 15-30 min before meals.
Contraindications
Hypersensitivity. Prolactinoma; conditions wherein stimulation of gastric motility could be harmful eg, GI haemorrhage, mechanical obstruction or perforation. Patients w/ known existing prolongation of cardiac conduction intervals, particularly QTc; significant electrolyte disturbances or underlying cardiac disease (eg, CHF). Co-administration w/ QT-prolonging drugs, potent CYP3A4 inhibitors (regardless of their QT-prolonging effects). Moderate or severe hepatic impairment.
Special Precautions
Associated w/ CV effects. Promptly report any cardiac symptoms. Patients w/ lactose intolerance, galactosaemia or glucose/galactose malabsorption. May affect ability to drive & use machines. Patients w/ severe renal impairment. Pregnancy & lactation. Not recommended in childn <12 yr & adolescents weighing <35 kg. Elderly >60 yr.
Adverse Reactions
Dry mouth. Loss of libido, anxiety, agitation, nervouness; dizziness, somnolence, headache, extrapyramidal disorder; diarrhea; rash, pruritus, urticaria; galactorrhoea, breast pain & tenderness; asthenia.
Drug Interactions
Should not be taken simultaneously w/ antacids or antisecretory drugs. Possible antagonised anti-dyspeptic effect w/ anticholinergic drugs. Contraindicated w/ QTc-prolonging medicinal drugs eg, anti-arrhythmics class IA (eg, disopyramide, hydroquinidine, quinidine), anti-arrhythmics class III (eg, amiodarone, dofetilide, dronedarone, ibutilide, sotalol), certain antipsychotics (eg, haloperidol, pimozide, sertindole), certain antidepressants (eg, citalopram, escitalopram), certain antibiotics (eg, erythromycin, levofloxacin, moxifloxacin, spiramycin), certain antifungal agents (eg, fluconazole, pentamidine), certain antimalarial agents (in particular halofantrine, lumefantrine), certain GI medicines (eg, cisapride, dolasetron, prucalopride), certain antihistaminics (eg, mequitazine, mizolastine), certain medicines used in cancer (eg, toremifene, vandetanib, vincamine), certain other medicines (eg, bepridil, diphemanil, methadone); apomorphine (unless benefit of co-administration outweighs the risks & recommended precautions are strictly fulfilled); potent CYP3A4 inhibitors eg, PIs (eg, ritonavir, saquinavir, telaprevir), systemic azole antifugals (eg, itraconazole, ketoconazole, posaconazole, voriconazole), certain macrolides (eg, clarithromycin, telithromycin). Not recommended w/ moderate CYP3A4 inhibitors (eg, diltiazem, verapamil & some macrolides). Caution w/ bradycardia & hypokalaemia-inducing drugs, azithromycin & roxithromycin.
ATC Classification
A03FA03 - domperidone ; Belongs to the class of propulsives. Used in the treatment of functional gastrointestinal disorders.
Presentation/Packing
Form
Motilium film-coated tab 10 mg
Packing/Price
100's
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