Motilium Tablets should be used at the lowest effective dose for the shortest duration necessary to control nausea and vomiting.
It is recommended to take Motilium Tablets before meals. If taken after meals, absorption of the drug is somewhat delayed.
Patients should try to take each dose at the scheduled time. If a scheduled dose is missed, the missed dose should be omitted and the usual dosing schedule resumed. The dose should not be doubled to make up for a missed dose.
Usually, the maximum treatment duration should not exceed one week.
Adults, and adolescents (12 years of age and older and weighing 35kg or more): One 10mg tablet up to three times per day with a maximum dose of 30mg per day.
Use in children under 12 years of age (and adolescents weighing less than 35kg): Not recommended.
Patients > 60 years of age: Patients older than 60 years of age should consult a healthcare professional before taking Motilium.
Hepatic Impairment: Motilium Tablets are contraindicated in moderate or severe hepatic impairment (see Contraindications). Dose modification in mild hepatic impairment is however not needed (see Pharmacology: Pharmacokinetics under Actions).
Renal Impairment: Since the elimination half-life of domperidone is prolonged in severe renal impairment, on repeated administration, the dosing frequency of Motilium Tablets should be reduced to once or twice daily depending on the severity of the impairment, and the dose may need to be reduced. Patients with severe renal impairment should be reviewed regularly (see Pharmacology: Pharmacokinetics under Actions).