Nateglinide


Concise Prescribing Info
Indications/Uses
Type 2 DM.
Dosage/Direction for Use
Adult : PO 60 or 120 mg tid. Max: 180 mg tid.
Dosage Details
Oral
Type 2 diabetes mellitus
Adult: 60 or 120 mg tid. Max: 180 mg tid.
Administration
Should be taken with food. Take immediately before or up to 30 min before meals.
Contraindications
IDDM, diabetic ketoacidosis.
Special Precautions
Patient w/ adrenal and/or pituitary impairment. Severe renal and moderate to severe hepatic impairment. Pregnancy and lactation.
Adverse Reactions
Hypoglycaemia, upper resp tract infection, back pain, flu-like symptoms, dizziness, arthropathy, diarrhoea, accidental trauma, bronchitis, cough.
MonitoringParameters
Monitor wt, lipid profile; fasting blood glucose and glycosylated Hb (HbA1c) levels.
Overdosage
Symptoms: Hypoglycaemia. Management: Use IV glucose in severe reaction.
Drug Interactions
CYP2C9 and CYP3A4 inhibitors or inducers may alter metabolism of nateglinide. Increased hypoglycaemic effects w/ MAOIs, nonselective β-adrenergic blockers, NSAIDs, salicylates. Decreased hypoglycaemic effects w/ corticosteroids, sympathomimetic agents, thiazide diuretics, thyroid hormones.
Food Interaction
Delayed absorption w/ food. Decreased serum concentration w/ St John's wort. Increased hypoglycaemic effects w/ alcohol.
Action
Description: Nateglinide, a nonsulfonylurea hypoglycaemic agent which stimulates insulin release from the pancreatic β-cells by blocking ATP-dependent K channels, depolarising the membrane and facilitating Ca entry through Ca channels. This action depends on the amount of existing glucose levels.
Onset: Approx 20 min.
Duration: 4 hr.
Pharmacokinetics:
Absorption: Rapidly absorbed from the GI tract. Food delays absorption. Bioavailability: 73%. Time to peak plasma concentration: W/in 1 hr.
Distribution: Volume of distribution: 10 L. Plasma protein-binding: 98%, primarily to albumin.
Metabolism: Hepatic metabolism via hydroxylation followed by glucuronide conjugation by CYP2C9 and CYP3A4 (lesser extent) isoenzymes.
Excretion: Mainly via urine (as unchanged drug and metabolites) and faeces (approx 10%). Elimination half-life: Approx 1.5 hr.
Chemical Structure

Click on icon to see table/diagram/image
Storage
Store at 25°C.
MIMS Class
ATC Classification
A10BX03 - nateglinide ; Belongs to the class of other blood glucose lowering drugs, excluding insulins. Used in the treatment of diabetes.
Disclaimer: This information is independently developed by MIMS based on Nateglinide from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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