Administration: It is recommended to take oral domperidone before meals. If taken after meals, absorption of the drug is somewhat delayed.
Dosage: Domperidone should be used at the lowest effective dose for the shortest duration and should not normally be used for longer than one week.
Patients should try to take each dose at the scheduled time. If a scheduled dose is missed, the missed dose should be omitted and the usual dosing schedule resumed. The dose should not be doubled to make up for a missed dose.
Usually, the maximum treatment duration should not exceed one week.
Adults and adolescents (12 years of age and older and weighing 35 kg or more): One 10 mg tablet up to three times per day with a maximum dose of 30 mg per day.
[Cross reference should be made to Precautions for further information.]
Hepatic impairment: Domperidone is contraindicated in moderate or severe hepatic impairment. Dose modification in mild hepatic impairment is however not needed.
Renal impairment: Since the elimination half-life of domperidone is prolonged in severe renal impairment, on repeated administration, the dosing frequency of domperidone should be reduced to once or twice daily depending on the severity of the impairment, and the dose may need to be reduced. Such patients on prolonged therapy should be reviewed regularly.
Paediatric population: The efficacy of domperidone in children less than 12 years of age has not been established.
The efficacy of domperidone in adolescents 12 years of age and older and weighing less than 35 kg has not been established.