Navelbine Oral/IV

Navelbine Oral/IV

vinorelbine tartrate


Pierre Fabre Medicament


Orient Europharma
Concise Prescribing Info
Vinorelbine ditartrate
Non-small cell lung cancer. Metastatic breast cancer.
Dosage/Direction for Use
Oral Monotherapy: 60 mg/m2 BSA once a wk for the 1st 3 doses, may be increased to 80 mg/m2 once a wk after the 3rd dose. Combination: 60 mg/m2 days 1 & 8 cycle 1, 80 mg/m2 days 1 & 8 thereafter every 3 wk. IV Non-small cell lung cancer & advanced breast cancer Monotherapy: 25-30 mg/m2 once wkly. Combination: 25-30 mg/m2 days 1 & 8 every 3 wk.
Should be taken with food: Take at the end of a meal. Swallow whole, do not chew/suck.
Known hypersensitivity to vinorelbine or other vinca alkaloids. Neutrophil count <1,500/mm3 or severe infection current or recent (w/in 2 wk). Combination w/ yellow fever vaccine. Pregnancy & lactation. Oral: GI disorder, history of extensive surgical resection of stomach or small intestine, severe hepatic insufficiency, fructose intolerance.
Special Precautions
Monitor hematological parameters during treatment. Infection, ischemic cardiac disease. Delay treatment if neutrophil count is <1,500/mm3 &/or platelet count is <75,000/mm3. Oral: Renal insufficiency, radiotherapy.
Adverse Reactions
Neutropenia, anemia, thrombocytopenia, nausea & vomiting, constipation & paralytic ileus, stomatitis & diarrhea, alopecia, fatigue, fever, arthralgia including jaw pain, myalgia, pain at tumor site. Oral: Anorexia, esophagitis, ataxia, neuromotor disorders. Rarely, ischemic heart disease, cutaneous reactions. Transient hepatic enzyme elevation. IV: Loss of tendon reflexes, weakness of lower extremities, dyspnea & bronchospasm, erythema, burning pain, vein discoloration & local phlebitis, pain at different locations.
Drug Interactions
Oral anticoagulants. Oral: Contraindicated w/ yellow fever vaccine. Phenytoin, fosphenytoin, live attenuated vaccine, ciclosporin, tacrolimus, itraconazole, mitomycin. IV: CYP3A4 inducers or inhibitors.
ATC Classification
L01CA04 - vinorelbine ; Belongs to the class of plant alkaloids and other natural products, vinca alkaloids and analogues. Used in the treatment of cancer.
Navelbine Oral softcap 30 mg
Navelbine IV inj 10 mg/mL
1 mL x 10 × 1's
Navelbine IV inj 50 mg/5 mL
5 mL x 10 × 1's
Navelbine Oral softcap 20 mg
Exclusive offer for doctors
Register for a MIMS account and receive free medical publications worth $768 a year.
Sign up for free
Already a member? Sign in