Neutropenia, anemia, thrombocytopenia, nausea & vomiting, constipation & paralytic ileus, stomatitis & diarrhea, alopecia, fatigue, fever, arthralgia including jaw pain, myalgia, pain at tumor site. Oral: Anorexia, esophagitis, ataxia, neuromotor disorders. Rarely, ischemic heart disease, cutaneous reactions. Transient hepatic enzyme elevation. IV: Loss of tendon reflexes, weakness of lower extremities, dyspnea & bronchospasm, erythema, burning pain, vein discoloration & local phlebitis, pain at different locations.