Neomycin + Dexamethasone + Acetic acid


Generic Medicine Info
Indications and Dosage
Otic/Aural
Otitis externa
Adult: 1 spray (60 mg) to each affected ear tid. Continue treatment until 2 days after symptoms have disappeared. Discontinue if there is no clinical improvement after 7 days.
Child: ≥2 yr Same as adult dose.
Contraindications
Hypersensitivity to neomycin sulfate, dexamethasone or glacial acetic acid. Known or suspected perforation of tympanic membrane or where a tympanostomy tube (grommet) is in situ.
Special Precautions
Childn. Pregnancy and lactation.
Adverse Reactions
Skin sensitisation or hypersensitivity leading to burning, stinging, irritation, itching and dermatitis.
Action
Description: Neomycin is a broad spectrum antibiotic while dexamethasone is a topical anti-inflammatory steroid. Acetic acid assist in the control of bacterial infection by producing a low pH.
Pharmacokinetics:
Distribution: Widely distributed in the surface.
Chemical Structure

Chemical Structure Image
Neomycin

Source: National Center for Biotechnology Information. PubChem Database. Neomycin, CID=8378, https://pubchem.ncbi.nlm.nih.gov/compound/Neomycin (accessed on Jan. 21, 2020)


Chemical Structure Image

Source: National Center for Biotechnology Information. PubChem Database. Dexamethasone, CID=5743, https://pubchem.ncbi.nlm.nih.gov/compound/Dexamethasone (accessed on Jan. 20, 2020)


Chemical Structure Image
Acetic acid

Source: National Center for Biotechnology Information. PubChem Database. Acetic acid, CID=176, https://pubchem.ncbi.nlm.nih.gov/compound/Acetic-acid (accessed on Jan. 22, 2020)

Storage
Store at or below 25°C. Do not freeze.
References
Joint Formulary Committee. Dexamethasone with Glacial Acetic Acid and Neomycin Sulfate . British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 06/04/2016.

Otomize (Forest Laboratories UK Limited). MHRA. https://products.mhra.gov.uk/ . Accessed 06/04/2016.

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