Neurobion Forte

Neurobion Forte

Manufacturer:

Procter & Gamble

Distributor:

Zuellig
/
Agencia Lei Va Hong
Full Prescribing Info
Contents
Thiamine mononitrate (vitamin B1 mononitrate), pyridoxine hydrochloride (vitamin B6 hydrochloride), cyanocobalamin (vitamin B12).
Description
Each coated tablet contains, as active ingredients, 100mg thiamine mononitrate (vitamin B1 mononitrate), 100mg pyridoxine hydrochloride (vitamin B6 hydrochloride), and 5000mcg cyanocobalamin (vitamin B12).
Action
Pharmacology: Pharmacodynamics: Properties: Neurobion FORTE contains vitamins B1, B6 and B12 which act as coenzymes and accordingly constitute substances essential for metabolism. Their role in the metabolism of different tissues including peripheral and central nerve cells, as well as their concomitant cells must be seen in correlation with the maintenance of the structural and functional properties of the nervous system. Further, in most of the populations such as elderly, diabetic individuals and others, deficiency of all three neurotropic vitamins is present.
Indications/Uses
Supplement of Vitamin B1, B6, B12 in cases of malnutrition, individuals on medication which has an influence on the vitamin status and others.
Dosage/Direction for Use
1 tablet daily with some liquid with or after meals.
Overdosage
No cases of overdose with thiamine or cyanocobalamin have been described.
Sensorial neuropathy and other sensorial neuropathy syndromes which can be caused by long-term administration of high doses of pyridoxine improve gradually upon discontinuation.
Contraindications
Individuals with hypersensitivity to any of the active ingredients or excipients of the product.
Children below the age of 14 years (due to the high doses of active ingredients).
Special Precautions
Neuropathies are described in the literature following long-term intake (6-12 months) of more than 50mg mean daily dose of vitamin B6. Therefore, regular monitoring is recommended under long-term usage.
Neurobion FORTE tablets contain lactose and sucrose; therefore its use is not recommended in individuals with rare hereditary galactose or fructose intolerance, glucose-galactose malabsorption, Lapp lactase deficiency, or sucrose-isomaltase insufficiency.
No effects of the product on the ability to drive or use machines are known.
Use In Pregnancy & Lactation
No risks have become known associated with the use of the product during pregnancy at the recommended dosage.
Thiamine, pyridoxine and cyanocobalamin are secreted into human breast milk, but risks of overdose for the infant are not known. In individual cases, high doses of vitamin B6, i.e. >600 mg daily, may inhibit the production of breast milk.
Adverse Reactions
Hypersensitivity reactions, such as sweating, tachycardia, and skin reactions with itching and urticaria.
Gastrointestinal complaints, such as nausea, vomiting, diarrhoea and abdominal pain.
Chromaturia ("reddish urine", appeared during the first 8 hours after an administration and typically resolves within 48 hours).
Drug Interactions
Vitamin B6 (pyridoxine) may decrease the effect of L-DOPA.
Pyridoxine antagonists such as isoniazid, cycloserine, penicillamine, or hydralazine may decrease the efficacy of vitamin B6 (pyridoxine).
Long-term use of loop diuretics such as furosemide may accelerate the elimination and thus decrease the serum levels of vitamin B1 (thiamine).
Long term use of acid-lowering agents may lead to vitamin B12 deficiency.
Storage
Do not store above 25°C. Keep in dry place.
ATC Classification
A11DB - Vitamin B1 in combination with vitamin B6 and/or vitamin B12 ; Used as dietary supplements.
Presentation/Packing
Coated tab 5 x 10's.
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