MI or myocardial ischaemia, GI perforation, drug-induced hepatitis & HTN or hypertensive crisis. Diarrhoea, fatigue, alopeica, infection, hand-foot skin reaction (palmar plantar erythrodysaesthesia sydrome) & rash. Lymphopenia. Anorexia, hypophosphataemia. Haemorrhage (including GI & resp tract & cerebral haemorrhage). Nausea, vomiting, constipation,. Dry skin, erythema, pruritus. Arthralgia. Mouth, abdominal, bone & tumour pain & headache, fever. Decreased wt, increased amylase & lipase.