There is very limited experience to date with deliberate overdose. The symptoms described in connection with an oral dose of 280 mg were gastrointestinal symptoms and weakness. Single oral doses of esomeprazole 80 mg and intravenous doses of esomeprazole 308 mg over 24 hours were uneventful. No specific antidote is known. Esomeprazole is extensively plasma protein bound and is, therefore, not readily dialyzable. As in any case of overdose, treatment should be symptomatic and general supportive measures should be utilised.