Patients with a history of hypersensitivity to any of the ingredients of this drug.
Patients with a history of hypersensitivity to thiazide group drugs or similar compounds (such as chlorthalidone and other sulfonamide derivatives).
Pregnant women or women suspected of being pregnant (see Use in Pregnancy & Lactation).
Patients with severe hepatic function disorder (see Careful Administration under Precautions).
Patients with anuria, and dialysis patients.
Patients with acute renal failure [This drug could further worsen renal function.]
Patients in whom sodium and potassium are clearly depleted in body fluids [This drug could worsen electrolyte imbalances such as hyponatremia and hypokalemia].
The concomitant use of NIKP-Losartan HCTZ film-coated tablet 50mg/12.5mg with aliskiren-containing products is contraindicated in patients with diabetes mellitus or renal impairment (GFR <60ml/min/1.73 m2).