Hypertension: Normally, the usual adult oral dose of NIKP-Losartan tablet 50mg or 100mg is 25 to 50 mg of losartan potassium once a day. Dose can be suitably increased or decreased in accordance with age or symptoms, but the dose can only be increased up to 100 mg per day.
Diabetic nephropathy in type 2 diabetes, followed with hypertension and proteinuria: Normally, the usual adult oral dose of NIKP-Losartan tablet 50mg or 100mg is 50 mg of losartan potassium once a day. The dose can be increased up to 100 mg per day while observing blood pressure values. However, for patients at risk of an excessive decrease in blood pressure, start administration from 25 mg.
Precautions Regarding Dosage and Administration: For diabetic nephropathy in type 2 diabetes, followed with hypertension and proteinuria, if after administration of NIKP-Losartan tablet 50mg, or NIKP-Losartan tablet 100mg, serum creatinine levels increase by 30% (or 1 mg/dL) or greater compared to previous testing levels, and if the propagation rate of renal function disorder is accelerating as assessed by glomerular filtration rate, slope of 1/serum creatinine levels, etc., consideration should be made into lowering the dosage or discontinuing administration.