Paracetamol B. Braun Solution for Infusion

Paracetamol B. Braun Solution for Infusion

paracetamol

Manufacturer:

B. Braun

Distributor:

DKSH
/
Four Star
Concise Prescribing Info
Contents
Paracetamol
Indications/Uses
Short-term treatment of moderate pain especially following surgery & of fever in adult, adolescent & childn weighing >33 kg.
Dosage/Direction for Use
50-mL bottle Childn & toddler weighing >10 to ≤33 kg 15 mg/kg (1.5 mL/kg), max of 60 mg/kg daily not exceeding 2 g daily. Max vol per administration: 49.5 mL. 100-mL bottle Adult, adolescent & childn weighing >50 kg & no additional risk factors for hepatotoxicity 1 g (100 mL), max of 4 g daily. Max vol per administration: 100 mL, >50 kg w/ additional risk factors for hepatotoxicity 1 g (100 mL), max of 3 g daily. Max vol per administration: 100 mL, >33 to ≤50 kg 15 mg/kg (1.5 mL/kg), max of 60 mg/kg daily not exceeding 3 g daily. Max vol per administration: 75 mL. Min interval between each administration must be at least 4 hr. Patient w/ severe renal impairment (CrCl ≤30 mL/min) Reduce dose & increase min interval between each administration to 6 hr. Adult w/ hepatocellular insufficiency, chronic alcoholism, chronic malnutrition (low reserves of hepatic glutathione), dehydration Max daily dose: 3,000 mg.
Contraindications
Hypersensitivity to paracetamol, propacetamol hydrochloride (prodrug); severe hepatocellular insufficiency.
Special Precautions
Avoid prolonged or frequent use. Risk of very serious liver damage in doses higher than those recommended. Use w/ caution in cases of hepatocellular insufficiency, severe renal insufficiency (CrCl ≤30 mL/min), chronic alcoholism, chronic malnutrition (low reserves of hepatic glutathione), dehydration, patients w/ genetically caused G6PD deficiency. Pregnancy.
Adverse Reactions
Inj site reactions (pain & burning sensation). Rarely, hypotension, increased hepatic transaminases, malaise.
Drug Interactions
Almost 2-fold reduction in clearance w/ probenecid. Prolonged elimination half-life w/ salicylamide. Caution w/ concomitant intake of enzyme-inducing substances. Concomitant use of paracetamol (4,000 mg/day for at least 4 days) w/ oral anticoagulants may lead to slight variations of INR values.
ATC Classification
N02BE01 - paracetamol ; Belongs to the class of anilide preparations. Used to relieve pain and fever.
Presentation/Packing
Form
Paracetamol B. Braun Solution for Infusion 1000 mg/100 mL
Packing/Price
100 mL x 10 × 1's
Form
Paracetamol B. Braun Solution for Infusion 500 mg/50 mL
Packing/Price
50 mL x 10 × 1's
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