Resp depression, COPD, increased intracranial pressure, bradycardia, potential for abuse & tolerance, serotonin syndrome. Nasal use only. Avoid use in case of recurrent episodes of epistaxis or nasal discomfort. Contains propyl parahydroxybenzoate; may cause allergic reactions. May impair ability to drive or operate machinery. Hepatic or renal impairment. Pregnancy & lactation. Childn.