Pentobarbitone - parenteral

Patient Medicine Information
Why do I need this medicine?
Pentobarbitone is used to treat sleeping problems (also known as insomnia) and it also helps you relax before surgery.

This medicine may also be used to treat seizures (fits) brought by other medical conditions e.g. eclampsia, meningitis, alcohol withdrawal and tetanus.

Pentobarbitone may also be used to treat other conditions as decided by your doctor.
How do I use this medicine?
Pentobarbitone injection is to be given intravenously (into the vein) or intramuscularly (into the muscles).

Your doctor or nurse will administer the injection for you.
What should I do if I have forgotten to use this medicine?
Ensure that you keep all appointments with your doctor so that you do not miss any doses.

If you miss an appointment or miss an injection, alert your doctor or nurse. A replacement appointment or injection should be given as soon as possible.

DO NOT double a dose under any circumstances.
When should I not use this medicine?
Alert your doctor if you have porphyria (an inherited disorder that may cause skin or nerve problems) as Pentobarbitone may not be suitable for you.
What should I take note of while using this medicine?
Inform your doctor if you have the following:

- liver disease
- kidney disease
- history of drug or alcohol abuse
- depression or suicidal tendencies

Let your doctor know if you are pregnant or breastfeeding.

For as long as you are using Pentobarbitone, your doctor needs to monitor your condition and check your response to the medication regularly.

Practise good sleeping habits to reduce reliance on sleeping pills. These are some good sleeping habits which you should follow:

- Try to relax before bedtime. Do not engage in strenuous activities.
- Try to go to bed at about the same time every night.
- Have a light dinner. A heavy dinner may disturb your sleep.
- Avoid caffeine in the evening. Caffeine-containing food and drink include coffee, tea, certain soft drinks and even chocolate.
- Keep your bedroom quiet, dark and airy.
- Avoid taking naps especially in the late afternoon.
What side effects could I experience?
Pentobarbitone may cause drowsiness and dizziness. If affected, do not drive or take part in any activity in which you need to be alert.

Other side effects include any of the following: headache, confusion, nausea, vomiting, constipation, nervousness, slow or shallow breathing, and pain and swelling at the injection site.

Some side effects may need immediate medical help. Alert your doctor quickly if you experience any of the following:

- confusion and hallucinations (seeing, hearing or feeling things that are not existent)
- unusual changes in mood or behaviour (being aggressive, agitated, or having compulsive and impulsive behaviour)
- slow heartbeat, fainting
- yellowing of the skin or eyes
- rashes, swollen mouth or eyes

Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Can I use this with other medicines?
Inform your doctor and pharmacist if you are taking any of these medicines:

- medicines to treat epilepsy (fits or seizures) e.g. valproic acid, phenytoin
- antibiotics e.g. doxycycline
- medicines to treat fungal infections e.g. griseofulvin
- other sleeping pills e.g. midazolam
- blood-thinning medicines e.g. warfarin
- birth-control pills

This list does not include all medicines that may interact with Pentobarbitone.

Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicine, supplements and medicines that you buy without a prescription.
What special dietary instructions should I follow?
Avoid alcohol.
How should I store this medicine?
Store in a cool, dry place away from the reach of children.

Do not freeze.

Medicines must not be used past the expiry date.
This information is independently developed by MIMS based on pentobarbitone - parenteral and is provided for your reference only. It is not a replacement for and should only be used in conjunction with full consultation with a licensed healthcare professional, the information provided by your pharmacist and/or the manufacturer of the medication. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, we shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by
Exclusive offer for doctors
Register for a MIMS account and receive free medical publications worth $768 a year.
Sign up for free
Already a member? Sign in