Phenylalpha

Phenylalpha Drug Interactions

phenylephrine

Manufacturer:

Laboratoire Aguettant

Distributor:

HK Medical Supplies

Marketer:

Aguettant
Full Prescribing Info
Drug Interactions
Contraindicated combinations (see Contraindications): Non-selective monoamine oxidase inhibitors (MAOs) (iproniazid, nialamide): Paroxysmal hypertension, hyperthermia possibly fatal. Due to the long duration of action of MAOIs, this interaction is still possible 15 days after discontinuation of the MAOI.
Inadvisable combinations: Dopaminergic ergot alkaloids (bromocriptine, cabergoline, lisuride, pergolide): Risk of vasoconstriction and/or hypertensive crisis.
Vasoconstrictor ergot alkaloids (dihydroergotamine, ergotamine, methylergometrine, methylsergide): Risk of vasoconstriction and/or hypertensive crisis.
Tricyclic antidepressants (e.g. imipramine): Paroxysmal hypertension with possibility of arrhythmias (inhibition of adrenaline or noradrenaline entry in sympathetic fibers).
Noradrenergic-serotoninergic antidepressants (minalcipram, venlafaxine): Paroxysmal hypertension with possibility of arrhythmias (inhibition of adrenaline or noradrenaline entry in sympathetic fibers).
Selective type A monoamine oxidase inhibitors (MAOs) (moclobemide, toloxatone): Risk of vasoconstriction and/or hypertensive crisis.
Linezolid: Risk of vasoconstriction and/or hypertensive crisis.
Guanethidine and related products: Substantial increase in blood pressure (hyperreactivity linked to the reduction in sympathetic tone and/or to the inhibition of adrenaline or noradrenaline entry in sympathetic fibers). If the combination cannot be avoided, use with caution lower doses of sympathomimetic agents.
Cardiac glycosides, quinidine: Increased risk of arrhythmias.
Sibutramine: Paroxysmal hypertension with possibility of arrhythmias (inhibition of adrenaline or noradrenaline entry in sympathetic fibers).
Halogenated volatile anaesthetics (desflurane, enflurane, halothane, isoflurane, methoxyflurane, sevoflurane): Risk of perioperative hypertensive crisis and arrhythmia.
Combinations requiring precautions for use: Oxytocic agents: The effect of presso-active sympathomimetic amines is potentiated. Thus, some oxytocic agents may cause severe persistent hypertension and strokes can occur during post-partum period.
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