Signs and Symptoms: Symptoms of overdosage are predominantly those of central nervous system depression and include somnolence, depressed level of consciousness, respiratory depression, coma, seizures, confusion, hallucination, agitation, abnormal electroencephalogram (burst suppression pattern and triphasic waves), accommodation disorder, impaired pupillary reflexes, muscular hypotonia, myoclonus, hyporeflexia or areflexia, hypotension or hypertension, bradycardia, tachycardia or cardiac arrhythmia, hypothermia, peripheral vasodilatation, nausea, vomiting, diarrhea, increased salivation, elevated LDH, AST, alkaline phosphatase, blood glucose values, sleep apnea and rhabdomyolysis.
The signs and symptoms may be further aggravated by co-administration of a variety of other agents including alcohol, diazepam, and tricyclic antidepressants.
Treatment: There is no specific antidote. Supportive measures and symptomatic treatment should be given for complications such as hypotension, hypertension, convulsions, gastrointestinal disturbances, and respiratory or cardiovascular depression.
After ingestion of a potentially toxic amount, activated charcoal should be considered, especially during the early period after ingestion. Gastric decontamination (e.g., gastric lavage) should be considered in individual cases, especially in the early period (60 minutes) after ingestion of a potentially life-threatening overdose. Comatose or convulsing patients should be intubated prior to the initiation of gastric decontamination. A high urinary output should be maintained since pms-BACLOFEN (baclofen) is excreted mainly by the kidneys. For this purpose, generous quantities of fluid should be administered, possibly together with a diuretic. Hemodialysis (sometimes unscheduled) is indicated in severe poisoning associated with renal failure (see Renal Impairment under Warnings). In the event of convulsions, administer diazepam IV with caution.