pms-Trazodone Dosage/Direction for Use





Full Prescribing Info
Dosage/Direction for Use
Dosing Considerations: Dosage should be initiated at a low level and increased gradually. It should be kept in mind that there may be a lag in the therapeutic response. Increasing the dosage rapidly does not normally shorten this latent period and may increase the incidence of side effects.
Recommended Dose and Dosage Adjustment: Adults: The recommended initial dose is 150-200 mg daily, in two or three divided doses. pms-TRAZODONE should be taken shortly after a meal or light snack in order to reduce the incidence of adverse reactions. The dose may be increased according to tolerance and response by increments of 50 mg, usually up to 300 mg daily in divided doses. In some patients, doses up to 400 mg daily and, rarely, up to 600 mg daily, may be required. Occurrence of drowsiness may require the administration of a major portion of the daily dose at bedtime or a reduction of dosage.
Once an adequate response has been achieved, the dosage may be gradually reduced, with adjustment depending on therapeutic response. During prolonged maintenance therapy the dosage should be kept at the lowest effective level.
Discontinuation of Treatment: Patients should be monitored for discontinuation symptoms when discontinuing treatment with pms-TRAZODONE. The dose should be gradually reduced whenever possible.
Geriatrics (>65 years of age): If used in the elderly, doses not exceeding half the recommended adult dosage should be used, with adjustments made depending on tolerance and response.
Pediatrics: pms-TRAZODONE is not indicated for use in children under 18 years of age.
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