Allergic Reactions: Advise patients to discontinue PRALUENT and seek prompt medical attention if any signs or symptoms of serious allergic reactions occur.
Instructions for Administration: Instruct patients and caregivers to read the Patient Information and Instructions For Use (IFU) before the patient starts using PRALUENT, and each time the patient gets a refill as there may be new information they need to know.
Provide guidance to patients and caregivers on proper subcutaneous injection technique, including aseptic technique, and how to use the pre-filled pen correctly (see Instructions for use under Cautions for Usage). Inform patients that it may take up to 20 seconds to inject PRALUENT.
The pre-filled pen should be allowed to warm to room temperature for 30 to 40 minutes prior to use.
Patients and caregivers should be cautioned that the pre-filled pen must not be re-used and instructed in the technique of proper pen and syringe disposal in a puncture-resistant container. Do not recycle the container.