Unless otherwise indicated, percentage of incidence is reported for patients with hypertension.
>10%: Endocrine and Metabolic: Hyperkalemia (19%, diabetic neuropathy; rarely seen in hypertension).
1% to 10%: Cardiovascular: Orthostatic hypotension (5%, diabetic nephropathy).
Central Nervous System: Fatigue (4%), dizziness (10%, diabetic nephropathy).
Gastrointestinal: Diarrhea (3%), dyspepsia (2%).
Respiratory: Upper respiratory infection (9%), cough (2.8% versus 2.7% in placebo).
<1%, Postmarketing, and/or Case Reports (limited to important or life threatening): Anemia (case report; Simonetti, 2007), angina, angioedema, arrhythmia, cardiopulmonary arrest, conjunctivitis, depression, dyspnea, ecchymosis, epistaxis, gout, heart failure, hepatitis, hypotension, jaundice, decreased libido, MI, orthostatic hypotension, paresthesia, renal failure, impaired renal function, sexual dysfunction, stroke, thrombocytopenia, increased transaminases, urticaria.