Special precautions for disposal and other handling: To reconstitute the vaccine, use only the solvent supplied, because it is free of preservatives or other antiviral substances, which might inactivate the vaccine. ProQuad, when reconstituted, is clear pale yellow to light pink liquid.
It is important to use a separate sterile syringe and needle for each individual to prevent transmission of infectious agents from one individual to another.
ProQuad must not be mixed in a syringe with other vaccines.
Reconstitution instructions: Inject the entire content of the syringe into the vial containing the powder. Gently agitate to dissolve completely. Withdraw the entire content of the reconstituted vaccine from the vial into the same syringe and inject the entire volume.
The reconstituted vaccine must not be used if any particulate matter is noted or if the appearance of the vaccine differs from that described previously.
It is recommended that the vaccine be administered immediately after reconstitution, to minimize loss of potency. Discard if reconstituted vaccine is not used within 30 minutes.
Any unused medicinal product or waste material should be disposed of in accordance with local requirements.
Incompatibilities: In the absence of compatibility studies, the vaccine must not be mixed with other medicinal products.