Protaphane/Protaphane Penfill諾和靈N

Protaphane/Protaphane Penfill

insulin isophane, human


Novo Nordisk


Firma Chun Cheong
Concise Prescribing Info
Isophane susp (NPH) of human insulin recombinant DNA origin
Dosage/Direction for Use
SC Individualized dosage. Usual insulin requirement: 0.3-1 IU/kg/day.
Special Precautions
Risk of hyperglycaemia w/ inadequate dosage or discontinuation of treatment, especially in type 1 diabetes. Risk of hypoglycaemia w/ excessive insulin dose; omitted meal or unplanned, strenous physical exercise. Change in usual warning symptoms of hypoglycaemia in patients w/ greatly improved blood glucose control eg, intensified therapy, & w/ longstanding diabetes. Transfer to another type or brand of insulin; change in strength, brand (manufacturer), type, origin (human insulin, insulin analogue) &/or method of manufacture. Rotate inj site continuously to reduce or prevent inj site reactions. Do not use in insulin infusion pumps. Cases of CHF in combination w/ thiazolidinediones. May impair ability to drive & use machines. Pregnancy & lactation.
Adverse Reactions
Hypoglycaemia. Refraction anomalies, oedema, inj site reactions (pain, redness, hives, inflammation, bruising, swelling, itching at inj site).
Drug Interactions
Reduced patient's insulin requirement w/ oral antidiabetics, MAOIs, non-selective β-blockers, ACE inhibitors, salicylates, anabolic steroids & sulphonamides. Increased patient's insulin requirement w/ OCs, thiazides, glucocorticoids, thyroid hormones, sympathomimetics, growth hormone & danazol. Masked symptoms & delayed recovery from hypoglycaemia w/ β-blockers. Either increased or decreased insulin requirements w/ octreotide/lanreotide. Intensified or reduced hypoglycemic effects w/ alcohol.
ATC Classification
A10AC01 - insulin (human) ; Belongs to the class of intermediate-acting insulins and analogues. Used in the treatment of diabetes.
Protaphane inj 100 IU/mL
(vial) 10 mL x 1's
Protaphane Penfill 100 IU/mL
3 mL x 5 × 1's
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