Risk of hyperglycaemia w/ inadequate dosage or discontinuation of treatment, especially in type 1 diabetes. Risk of hypoglycaemia w/ excessive insulin dose; omitted meal or unplanned, strenous physical exercise. Change in usual warning symptoms of hypoglycaemia in patients w/ greatly improved blood glucose control eg, intensified therapy, & w/ longstanding diabetes. Transfer to another type or brand of insulin; change in strength, brand (manufacturer), type, origin (human insulin, insulin analogue) &/or method of manufacture. Rotate inj site continuously to reduce or prevent inj site reactions. Do not use in insulin infusion pumps. Cases of CHF in combination w/ thiazolidinediones. May impair ability to drive & use machines. Pregnancy & lactation.
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