Racecadotril


Generic Medicine Info
Indications and Dosage
Oral
Acute diarrhoea
Adult: 100 mg tid. Continue treatment until 2 normal stools are recorded. Max duration of treatment: 7 days.
Child: In combination with oral rehydration salts: Recommended dose: 1.5 mg/kg/dose tid.  Max dose: 6mg/kg daily. ≥3-9 months <9 kg: 10 mg tid. 9-30 months 9-13 kg: 20 mg tid. 30 months to 9 years 13-27 kg: 30 mg tid. >9 years >27 kg: 60 mg tid. Continue treatment until 2 normal stools are recorded. Max duration: 7 days.
Administration
May be taken with or without food.
Reconstitution
Add granules to food, dispersed in a glass of water or in the feeding bottle, mix well and administer immediately.
Contraindications
Children with fructose intolerance, glucose malabsorption syndrome or sucrase-isomaltase deficiency (granules).
Special Precautions
Patient with history of angioedema. Children.
Adverse Reactions
Significant: Angioedema.
Respiratory, thoracic and mediastinal disorders: Tonsillitis.
Skin and subcutaneous tissue disorders: Rash, erythema, urticaria, erythema multiforme, nodular erythema, papular rash, prurigo, pruritus.
Potentially Fatal: Skin reactions.
Food Interaction
Food delays peak activity by approx 90 minutes.
Action
Description: Racecadotril is a prodrug of thiorphan, an enkephalinase inhibitor. It achieves its antisecretory effect by protecting enkephalins from enzymatic degradation thereby prolonging their action at enkephalinergic synapses in the small intestine and reducing hypersecretion.
Duration: Approx 8 hours (enkephalinase inhibition).
Pharmacokinetics:
Absorption: Rapidly absorbed. Time to peak plasma enkephalinase inhibition: Approx 2 hours.
Distribution: Plasma protein binding: 90% (mainly albumin).
Metabolism: Rapidly hydrolysed to thiorphan, the active metabolite, which is in turn transformed to inactive metabolites.
Excretion: Mainly via urine (81.4%), via faeces (approx 8%). Elimination half-life: Approx 3-4 hours.
Chemical Structure

Chemical Structure Image
Racecadotril

Source: National Center for Biotechnology Information. PubChem Database. Racecadotril, CID=107751, https://pubchem.ncbi.nlm.nih.gov/compound/Racecadotril (accessed on Jan. 22, 2020)

Storage
Store below 25°C.
MIMS Class
ATC Classification
A07XA04 - racecadotril ; Belongs to the class of other antidiarrheals.
References
Anon. Racecadotril. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 11/10/2019.

Buckingham R (ed). Racecadotril. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 17/09/2019.

Hidrasec 100 mg Capsule (Abbott Products Inc.). MIMS Philippines. http://www.mims.com/philippines. Accessed 14/10/2019.

Hidrasec 100 mg Hard Capsules (Abbott Laboratories Ltd.). MIMS Thailand. http://www.mims.com/thailand. Accessed 14/10/2019.

Hidrasec Granules for Oral Suspension (Abbott Products Inc.). MIMS Philippines. http://www.mims.com/philippines. Accessed 14/10/2019.

Hidrasec Paediatric (Abbott Laboratories Ltd.). MIMS Thailand. http://www.mims.com/thailand. Accessed 14/10/2019.

Disclaimer: This information is independently developed by MIMS based on Racecadotril from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by MIMS.com
  • Hidrasec
Exclusive offer for doctors
Register for a MIMS account and receive free medical publications worth $768 a year.
Sign up for free
Already a member? Sign in