Initially 25 mg once daily, may be adjusted to 25-75 mg once daily. Increase dose by 25 mg at 3-wk intervals up to 100 mg once daily if required or if there is no improvement on the parathyroid hormone (PTH).
Determine serum Ca & PTH level prior to & periodically during therapy. Decrease dose as needed if serum Ca level is ≤8.4 mg/dL or w/draw if ≤7.5 mg/dL. Hypocalcemia, seizure, hepatic dysfunction, GI hemorrhage &/or ulcer, adynamic bone disease, hungry bone syndrome. Patients not on dialysis. Pregnancy & lactation. Infant & childn. Elderly.