Laboratorios Rubio


Concise Prescribing Info
Treatment of hypercholesterolaemia & pruritus associated w/ partial biliary obstruction or primary biliary cirrhosis.
Dosage/Direction for Use
Adult 1 sachet (4 g) tds-qds (12-16 g/day). Childn ½ sachet (2 g) bd-qds (4-8 g/day) in 2 separate doses, preferably, before breakfast & dinner.
Should be taken on an empty stomach: Dissolve in ½ glass of water/milk/fruit juice.
Hypersensitivity. Complete biliary obstruction. Pregnancy & lactation.
Special Precautions
Do not take as a dry powd. Risk of transient increase in serum triglyceride levels when used as monotherapy; serum or RBC folate reduction on prolonged use; hyperchloraemic acidosis; increase in urinary excretion of Ca. May interfere w/ normal fat absorption, including lipid soluble vit from diet (A, D, E & K) when given at high doses. Can cause or aggravate constipation or haemorrhoids. Use w/ caution in patients w/ active peptic ulcer or history of ulcers. Regular assessment of serum cholesterol & triglyceride level is recommended. Patients w/ low Na diet. Pregnancy & lactation.
Adverse Reactions
Constipation, dyspepsia, flatulence, nausea, vomiting.
Drug Interactions
Reduced plasma levels of amiodarone; paracetamol; antidepressants (eg, doxepin, imipramine). Increased effects of anticoagulants (eg, warfarin). Reduced AUC of antidiabetic drugs (eg, glipizide); mycophenolate mofetil; tetracyclines. Decreased absorption of barbiturates; antimalarial agents (eg, chloroquine); raloxifene; liposoluble vit (A, D, E & K). Reduced bioavailability & max serum conc of anti-inflammatory drugs (eg, diclofenac, phenylbutazone, ibuprofen). Reduced elimination t½ of oxicam-type anti-inflammatory drugs (eg, meloxicam, piroxicam, tenoxicam); cardiotonic drugs (eg, digoxin & other glycosides). Reduced peak plasma levels & AUC of β-blockers (eg, propranolol). Reduced AUC & decreased effects of corticosteroids (eg, hydrocortisone). Reduced bioavailability & therapeutic activity of thiazide diuretics (eg, furosemide, hydrochlorothiazide). Reduced enterohepatic circulation of oestrogens & progestogens. Possible reduction in plasma levels of statins (eg, fluvastatin, pravastatin). Inhibited effects of loperamide. Reduced bioavailability of metronidazole. Reduced absolute bioavailability of sulindac & its metabolites. Inhibition of thyroid effects of thyroid hormones (eg, levothyroxine, liothyronine). Reduced AUC & max plasma conc of valproic acid. Possible potentiated effects of acarbose.
ATC Classification
C10AC01 - colestyramine ; Belongs to the class of bile acid sequestrants. Used in the treatment of hyperlipidemia.
Resincolestiramina powd for oral susp 4 g
50 × 1's
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