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Indications and Dosage
Otic/Aural
Purulent otorrhoea Adult: As 26 mg/mL solution: Instill 5 drops onto affected ear(s) bid for 7 days. Child: As 26 mg/mL solution: Instill 3 drops onto affected ear(s) bid for 7 days. Topical/Cutaneous Susceptible infections Adult: As 10 mg/mL spray solution: Spray unto affected area(s) 6-8 hourly or as directed.
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Contraindications
Hypersensitivity.
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Special Precautions
Prolonged use. Hepatic impairment. Pregnancy and lactation.
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Adverse Reactions
Significant: Hypersensitivity (e.g. rashes, pruritus, and rarely, anaphylaxis). Reddish discolouration of urine and body fluids.
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Patient Counseling Information
This drug may cause permanent staining, remove dentures and soft contact lenses during therapy. May produce red discolouration of urine and other body fluids.
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Action
Description: Rifamycin suppresses initiation of chain formation for RNA synthesis in susceptible bacteria by binding to the β subunit of DNA-dependent RNA polymerase, thus blocking RNA transcription.
Pharmacokinetics: Distribution: Plasma protein binding: Approx 80%. Excretion: Mainly via faeces; urine (small amount). Elimination half-life: Approx 1 hour. |
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Chemical Structure
 Source: National Center for Biotechnology Information. PubChem Database. Rifamycin, CID=6324616, https://pubchem.ncbi.nlm.nih.gov/compound/Rifamycin (accessed on Jan. 22, 2020) |
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Storage
Store below 30°C. Protect from light and moisture.
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MIMS Class
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ATC Classification
S02AA12 - rifamycin ; Belongs to the class of antiinfectives used in the treatment of ear infections.
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References
Buckingham R (ed). Rifamycin Sodium. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 07/05/2018.
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