Increased effect w/ halogenated volatile anaesth; w/ high doses of thiopental, methohexital, ketamine, fentanyl, gammahydroxybutyrate, etomidate, propofol; after intubation w/ or prior administration of suxamethonium; long-term concomitant use w/ corticosteroids in ICU; antibiotics eg, aminoglycosides, lincosamides (lincomycin & clindamycin), polypeptide antibiotics, acylamino-penicillin antibiotics, tetracyclines, high doses of metronidazole; diuretics, quinidine & its isomer quinine, protamine, adrenergic blocking agents, Mg salts, Ca channel blocking agents, lithium salts & local anaesth (lidocaine IV, bupivacaine epidural) & acute administration of phenytoin or β-blocking agents. Reports of recurarization after post-op administration of aminoglycoside, lincosamide, polypeptide & acylamino-penicillin antibiotics, quinidine, quinine & Mg salts. Decreased effect w/ neostigmine, edrophonium, pyridostigmine, aminopyridine derivatives; prior chronic administration of phenytoin or carbamazepine; PIs. Attenuated/potentiated neuromuscular block w/ other non-depolarising neuromuscular blocking agents. Faster onset of lidocaine effect.