Romiplostim - subcutaneous

Patient Medicine Information
Why do I need this medicine?
Romiplostim is used to treat chronic idiopathic thrombocytopenic purpura or ITP, a bleeding disorder in which the immune system destroys platelets.
How do I use this medicine?
Romiplostim should be injected subcutaneously (into the fatty layer under the skin, usually in the thigh, upper arm or abdomen area) once a week.

Your doctor or nurse will administer the injection for you. Do not administer this medicine by yourself unless trained with proper reconstitution and administration techniques by your doctor.

If you are already eligible for self-administration of this medicine, follow these steps:
  1. Dissolve your Romiplostim solution for injection as instructed by your doctor, nurse, or pharmacist.
  2. Pull back the pink safety cover away from the needle.
  3. Remove the needle shield carefully.
  4. Gently pinch the area of skin and hold it firmly. Hold the syringe like a pencil at a 45-degree angle to the skin.
  5. Push the needle into the skin.
  6. Inject the prescribed dose as directed by your doctor, nurse, or pharmacist.
  7. When the syringe is empty, pull the needle out of the skin.
  8. A little bleeding may occur at the injection site. Press a cotton ball or gauze over the area for 10 seconds. If needed, you may cover it with a plaster.
  9. After injecting, use your thumb or tip of your finger to activate the pink safety cover. Ensure that the needle tip is covered.
  10. Always cover the needle with the pink safety cover before disposal.
Remember to rotate the injection sites. Do not inject into the same area all the time. If you need help with understanding the instructions, ask your doctor or pharmacist.

Throw away the used needle according to your doctor or pharmacist’s instructions. Use a new needle for each injection.

DO NOT inject Romiplostim intravenously (into a vein) or intramuscularly (into a muscle).

Do not share your Romiplostim injection with anyone else.

This medicine should be administered regularly for it to be effective. Do not stop using it unless instructed by your doctor. Your condition may worsen if Romiplostim is stopped suddenly.
What should I do if I have forgotten to use this medicine?
If you miss an injection, alert your doctor or nurse. A replacement injection should be given as soon as possible.

DO NOT double a dose under any circumstances.

If you often forget to use your medicine, let your doctor and pharmacist know.
What should I take note of while using this medicine?
Inform your doctor if you have the following conditions:
  • inherited or acquired blood disorders
  • kidney disease
  • risk factors of having blood clots e.g. old age,prolonged immobilisation, cancer, contraceptive use, hormone replacement therapy, recently had surgery or injury, obesity, smoker smoking, history of stroke
Let your doctor know if you are pregnant or breastfeeding.

If you are going for an operation, including minor surgery and dental work, inform your doctor or dentist that you are taking Romiplostim.

Do not participate in activities in which you may fall or get injured, such as contact sports. Alert your doctor if you get any unusual bruising (large bruises or several bruises) or bleeding that takes a long time to stop (e.g. too much bleeding when you floss or brush your teeth).

If you smoke, you should try to quit. Smoking is harmful to your blood vessels and overall health. It has been shown that smoking will make your condition worse. Speak to your doctor or pharmacist about ways to kick your smoking habit.

Regular exercise will help to gradually improve your condition by improving your blood circulation. However, you should not over-exert yourself. Speak to your doctor about what type of exercise would be suitable for you.

Keep your appointments with your doctor. Your doctor needs to monitor your condition and check your response to the medication regularly. Your doctor may also need to do routine blood tests (e.g. complete blood count including platelet counts) before, during and after discontinuation of treatment.
What side effects could I experience?
Romiplostim may cause dizziness. If affected, do not drive or take part in any activity in which you need to be alert or need to see clearly.

Other side effects include any of the following: headache, tiredness, difficulty sleeping, nausea, diarrhoea, stomach pain, indigestion, constipation, muscle pain, joint pain, limb pain, shoulder pain, numbness or tingling sensation in the hands and feet, and pain, redness, and swelling at the injection site.

Some side effects may need immediate medical help. Alert your doctor quickly if you experience any of the following:
  • shortness of breath and chest pain
  • pain and swelling in your arms and legs
  • redness of skin with unusual bleeding or bruising
  • swelling of the face, lips, mouth, tongue, or throat
Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Can I use this with other medicines?
Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.
What special dietary instructions should I follow?
Avoid alcohol.
How should I store this medicine?
Store in the refrigerator, between 2-8 °C. Do not allow to freeze. If frozen, this medicine will become ineffective and should not be used.

Protect from light.

Medicines must not be used past the expiry date.
This information is independently developed by MIMS based on romiplostim - subcutaneous and is provided for your reference only. It is not a replacement for and should only be used in conjunction with full consultation with a licensed healthcare professional, the information provided by your pharmacist and/or the manufacturer of the medication. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, we shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by
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