Ryzodeg

Ryzodeg

Manufacturer:

Novo Nordisk

Distributor:

Firma Chun Cheong
/
DKSH
Concise Prescribing Info
Contents
Insulin degludec 70%, insulin aspart 30%
Indications/Uses
DM in adults, adolescents & childn ≥2 yr.
Dosage/Direction for Use
SC Ryzodeg can be administered once daily or bd. Type 2 DM Initially 10 u followed by individual dose adjustments. Can be administered alone, in combination w/ oral antidiabetics, & in combination w/ bolus insulin. Type 1 DM Initially 60-70% of the total daily insulin requirements. Use once daily in combination w/ short-/rapid-acting insulin followed by individual dose adjustments.
Administration
Should be taken with food.
Contraindications
Special Precautions
Risk of hypoglycaemia. Inadequate dosing &/or discontinuation of treatment may lead to hyperglycaemia & diabetic ketoacidosis. Concomitant illness, especially infections. Transfer from other insulin medicinal products. Risk of cardiac failure when used in combination w/ thiazolidinediones. Intensification of insulin therapy w/ abrupt improvement in glycaemic control may be associated w/ temporary worsening of diabetic retinopathy. Insulin Ab formation. May impair ability to drive or use machine. Pregnancy & lactation. Childn 2-5 yr.
Adverse Reactions
Hypoglycaemia. Inj site reactions.
Drug Interactions
Reduced patient's insulin requirements w/ oral antidiabetics, GLP-1 receptor agonists, MAOIs, β-blockers, ACE inhibitors, salicylates, anabolic steroids & sulfonamides. Increased patient's insulin requirements w/ OCs, thiazides, glucocorticoids, thyroid hormones, sympathomimetics, growth hormone & danazol. β-blockers may mask symptoms of hypoglycaemia. Increased/decreased insulin requirements w/ octreotide/lanreotide. Intensified/reduced hypoglycaemic effects of insulin w/ alcohol.
ATC Classification
A10AD06 - insulin degludec and insulin aspart ; Belongs to the class of intermediate-acting combined with fast-acting insulins and analogues. Used in the treatment of diabetes.
Presentation/Packing
Form
Ryzodeg soln for inj (pre-filled pen) 100 u/mL
Packing/Price
3 mL x 5 × 1's
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