Secnidazole


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : PO Invasive amoebiasis 1.5 g/day for 5 days. Amoebiasis; Giardiasis; Trichomoniasis Single dose of 2 g.
Dosage Details
Oral
Severe invasive amoebiasis
Adult: 1.5 g daily as single or in divided doses for 5 days.
Child: 30 mg/kg daily for 5 days.

Oral
Trichomoniasis, Amoebiasis, Giardiasis
Adult: 2 g as a single dose.
Child: 30 mg/kg as a single dose.
Contraindications
Hypersensitivity; pregnancy (1st trimester) and lactation.
Special Precautions
Avoid alcohol and disulfiram. Avoid in patients with history of blood disorders.
Adverse Reactions
Nausea, gastralgia, change of taste, metallic taste, stomatitis, urticaria, rashes, leucopenia. Rarely vertigo, moderate neurological, digestive disturbances.
Drug Interactions
Concurrent disulfiram admin may cause psychotic reactions. Disulfiram-like reactions with alcohol. Cimetidine may prolong half-life.
Potentially Fatal: May potentiate anticoagulant effect of warfarin and increase risk of haemorrhage.
Action
Description: Secnidazole is active against E histolytica, G lamblia, T vaginalis, Clostridium spp, B fragilis, Gardnerella spp. The drug enters the microorganisms by diffusion and is reduced intracellularly by low oxidation-reduction potential ferredoxin which then result in DNA damage.
MIMS Class
Disclaimer: This information is independently developed by MIMS based on Secnidazole from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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