Dextromethorphan hydrobromide, pseudoephedrine hydrochloride, promethazine hydrochloride.
Each 5 ml linctus contains: Dextromethorphan Hydrobromide 15mg, Pseudoephedrine Hydrochloride 30mg, Promethazine Hydrochloride 3.125mg.
Parabens 0.125%w/v as preservative.
Dextromethorphan is a non-narcotic cough suppressant which acts centrally to raise the threshold for coughing. Its effectiveness in suppressing cough has been found to be about equal to codeine. Pseudoephedrine hydrochloride is used as a nasal and bronchial decongestant. It is said to have less pressor activity and CNS effects than ephedrine of which it is a stereoisomer. Promethazine hydrochloride is a H1-receptor blocking agent. In therapeutic dosages, promethazine produces no significant effects on the cardiovascular system.
Sedilix-DM is indicated for the relief of dry irritating coughs such as those associated with common cold or upper respiratory tract infections.
Sedilix-DM helps to relieve nasal congestion, sneezing and rhinorrhea associated with allergy and the common cold.
Adults and children over 12 years: 10ml every 6 hours.
Children 6 to 12 years: 5ml every 6 hours.
In case of overdosage, hospital admission is strongly advised. Overdosage may produce respiratory depression, paranoid psychosis, delusions, hallucinations, and convulsion.
Treatment should include emptying the stomach by aspiration or gastric lavage. Nervous stimulation and convulsions should be treated with a sedative such as diazepam intamuscularly. If marked excitation is present, a sedative such as diazepam or a short-acting barbiturate may be given.
Elimination of pseudoephedrine may be assisted by acidification of the urine with ammonium chloride. Other symptomatic and supportive treatments should be given.
Sedilix-DM should not be taken for persistent or chronic cough (eg with smoking, emphysema, asthma) or when coughing is accompanied by excessive secretions unless directed by a physician.
It should be avoided in patients with liver disease or asthmatic patients and is contraindicated in patients taking monoamine oxidase inhibitors and within 2 weeks from stopping treatment, known hypersensitivity to pseudoephedrine and during acute attacks of asthma.
This may cause drowsiness. If affected, do not drive or operate machinery. Avoid taking alcoholic drink.
Use with caution in patients with epilepsy, prostatic hypertrophy, glaucoma, hepatic disease, hypertension, heart disease, diabetes, hyperthyroidism, patients with stenosing peptic ulcer, pyloro-duodenal obstruction or bladder neck obstruction, unless under the medical advice and supervision.
If symptoms do not improve within one week or accompanied with high fever, consult a physician before continuing use.
As with any other drugs, use in pregnancy is best avoided.
Sedilix-DM may cause drowsiness, dizziness and constipation.
Other side effects that may occur include GIT discomfort. No apparent evidence of physical dependence of the morphine type.
Other less common side-effects may include transient hypertension, dry mouth, insomnia, restlessness, palpitations, allergic reactions such as rashes, tightness of chest, thickening of bronchial secretions, toxic psychosis and blood dyscrasia.
Possible reactions systemically may occur with betahistine, certain hypnotic and anxiolytic medication, metoclopramide and antiparkinson drugs.
Incompatibilities: This preparation is incompatible in solution with aminophylline, barbiturates, benzylpenicillin salts, carbenicillin and heparin.
Store in a cool place below 25°C.
R05DA20 - combinations ; Belongs to the class of opium alkaloids and derivatives. Used as cough suppressant.
Linctus (brown syrup) 90 mL, 120 mL.