Siltuximab - intravenous

Patient Medicine Information
Why do I need this medicine?
Siltuximab is used to treat multicentric Castleman’s Disease (non-cancerous growths in the lymph nodes) to those who do not have human immunodeficiency virus (HIV) or human herpesvirus-8 (HHV-8) infection.
How do I use this medicine?
The dose of this medicine will be decided by your doctor. Your doctor will advise you on the course of your treatment depending on your condition.

Siltuximab is to be given intravenously (into the vein) infusion. It is delivered directly into the bloodstream via the blood vessel.

Your doctor or nurse will administer the injection for you.
What should I do if I have forgotten to use this medicine?
Ensure that you keep all appointments with your doctor so that you do not miss any doses. Your doctor also needs to regularly monitor your response to Siltuximab.

If you miss an appointment or miss an injection, alert your doctor or nurse. A replacement appointment or injection should be given as soon as possible.
When should I not use this medicine?
Alert your doctor if you have been recently vaccinated. Do not receive any vaccinations as this medicine may not be suitable for you.
What should I take note of while using this medicine?
Inform your doctor if you have the following conditions:
  • severe infection
  • stomach or bowel problems (e.g. stomach ulcer or diverticulitis) or any other conditions which may increase the risk of getting a tear in the stomach
Let your doctor know if you are pregnant or breastfeeding.

You must use an effective contraception during and for up to 3 months after stopping the treatment. You may wish to discuss birth control methods with your doctor or pharmacist.

Keep your appointments with your doctor. Your doctor needs to monitor your condition and check your response to the medication regularly.
  • You may need to have routine blood tests (e.g. complete blood count with differential) while you are being treated with Siltuximab. Your doctor will advise you about how often you will need to have these tests.
  • Regular monitoring for signs and symptoms of an allergic or infusion related reaction, infection, or stomach pain and tenderness which could be a sign of a tear in the stomach may also be needed.
What side effects could I experience?
Siltuximab may cause any of the following side effects: stomach pain, diarrhoea, constipation, common cold, weight gain, headache, tiredness, joint pain and respiratory infections.

Some side effects may need immediate medical help. Alert your doctor quickly if you experience any of the following:
  • signs of an allergic or infusion related reaction e.g. difficulty breathing, chest tightness, wheezing, dizziness or light headedness, swelling of the lips, skin rash
  • signs of an infection e.g. fever, chills, sore throat or mouth sore
Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Can I use this with other medicines?
Do not receive any vaccinations. Alert your doctor if you have been recently vaccinated.

Inform your doctor if you are currently taking birth control pills as this can reduce the effectiveness of Siltuximab. You should not stop or start any birth control pills without first informing your doctor. Ask your doctor about using non-hormonal birth control as an alternative while being treated with this medicine.

Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.
What special dietary instructions should I follow?
Avoid alcohol.
How should I store this medicine?
Store in the refrigerator, between 2-8 °C. Do not allow to freeze. If frozen, this medicine will become ineffective and should not be used.

Protect from light. Keep away from the reach of children.

Medicines must not be used past the expiry date.
This information is independently developed by MIMS based on siltuximab - intravenous and is provided for your reference only. It is not a replacement for and should only be used in conjunction with full consultation with a licensed healthcare professional, the information provided by your pharmacist and/or the manufacturer of the medication. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, we shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by
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