Silver sulfadiazine


Concise Prescribing Info
Indications/Uses
Treatment and prevention of infection in severe burns.
Dosage/Direction for Use
Adult : Topical As 1% cream: Apply onto affected area 1-2 times/day.
Dosage Details
Topical/Cutaneous
Treatment and prophylaxis of infection in severe burns
Adult: Apply a 1% cream onto affected area once or twice daily.
Contraindications
Hypersensitivity to sulphonamides; porphyria; premature infants and infants <2 mth; pregnancy and lactation.
Special Precautions
Impaired hepatic or renal function; G6PD deficiency; maintain adequate fluid intake. Monitor blood counts. Systemic absorption, resulting in argyria may occur if it is applied to large wound areas and over prolonged periods.
Adverse Reactions
Nausea, vomiting, diarrhoea; hypersensitivity, skin reactions; haematuria; crystalluria; thrombocytopenia, leucopenia, eosinophilia.
Potentially Fatal: Stevens-Johnson syndrome; agranulocytosis, jaundice, hepatitis.
Drug Interactions
Potentiates antidiabetic effect of sulphonylureas. Not antagonised by PABA.
Action
Description: Silver sulfadiazine has broad antimicrobial activity; it is active against gram-positive and gram-negative bacteria as well as some yeasts and fungi. The silver salt acts mainly on the cell wall and membrane to disrupt its intergrity thus allowing it to impair the essential enzymes, bacterial DNA and RNA leading to cell death.
Pharmacokinetics:
Absorption: Slowly releases sulfadiazine when it comes into contact with wound exudates. Up to 10% of sulfadiazine may be absorbed.
Disclaimer: This information is independently developed by MIMS based on Silver sulfadiazine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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