SMOFlipid

SMOFlipid

Manufacturer:

Fresenius Kabi

Distributor:

Zuellig
/
The Glory Medicina
Concise Prescribing Info
Contents
Per L Refined soya bean oil 60 g, medium-chain triglycerides 60 g, refined olive oil 50 g, fish oil (omega 3) 30 g
Indications/Uses
Supply of energy, essential fatty acids & omega-3 fatty acids to patients as part of parenteral nutrition regimen when oral or enteral nutrition is impossible, insufficient or contraindicated.
Dosage/Direction for Use
IV infusion into peripheral or central vein. Adult 1-2 g fat/kg/day at an infusion rate of 0.125 g fat/kg/hr. Max infusion rate: 0.15 g fat/kg/hr. Childn Max daily dose: 3 g fat/kg. Gradually increase during the 1st wk of therapy. Max infusion rate: 0.15 g fat/kg/hr. Neonate & infant Initially 0.5-1 g fat/kg/day followed by successive increase of 0.5-1 g fat/kg/day up to 3 g fat/kg/day. Max daily dose: 3 g fat/kg. Max infusion rate: 0.125 g fat/kg/hr. For premature & low birth wt neonates, continuously infuse over 24 hr.
Contraindications
Hypersensitivity to fish, egg, soya or peanut protein. Severe hyperlipidemia, severe liver insufficiency, severe blood coagulation disorders, severe renal insufficiency w/o access to hemofiltration or dialysis, acute shock, acute pulmonary oedema, hyperhydration, decompensated cardiac insufficiency, severe posttraumatic conditions, uncompensated DM, acute MI, stroke, embolism, metabolic acidosis, severe sepsis & hypotonic dehydration.
Special Precautions
Monitor capacity to eliminate fat. Patient at risk to hyperlipidemia eg, w/ high lipid dosage, severe sepsis & extremely low birth wt infant. Impaired lipid metabolism in patient w/ renal failure, DM, pancreatitis, liver impairment, hypothyroidism & sepsis. Monitor blood glucose levels, liver function tests, acid-base metabolism, fluid balance, FBC & electrolytes. Neonate & premature neonate w/ hyperbilirubinemia & pulmonary HTN. Pregnancy & lactation.
Adverse Reactions
Drug Interactions
Transient increase in lipoprotein lipase release into the circulation which may initially result in increased plasma lipolysis, followed by a transient decrease in triglyceride clearance w/ heparin.
MIMS Class
Parenteral Nutritional Products
ATC Classification
B05BA02 - fat emulsions ; Belongs to the class of solutions for parenteral nutrition used in I.V. solutions.
Presentation/Packing
Form
SMOFlipid emulsion for infusion
Packing/Price
100 mL x 1's
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