For optimal absorption, it is essential to administer Sporanox immediately after a full meal. The capsules must be swallowed whole.
Vulvovaginal Candidosis: 200 mg twice daily for 1 day or 200 mg once daily for 3 days.
Pityriasis versicolor: 200 mg once daily for 7 days.
Dermatomycosis: 200 mg once daily for 7 days or 100 mg daily for 15 days.
Highly keratinized regions as in plantar tinea pedis and palmar tinea manus require 200 mg twice daily for 7 days, or 100 mg daily for 30 days.
Oral Candidosis: 100 mg once daily for 15 days.
In some immunocompromised patients eg, neutropenic, AIDS or organ transplant patients, the oral bioavailability of itraconazole may be decreased. Therefore, the doses may need doubling.
Fungal Keratitis: 200 mg once daily for 21 days.
Onychomycosis: Pulse treatment (see table).
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A pulse treatment consists of 2 caps twice daily (200 mg twice daily) for 1 week. Two pulse treatments are recommended for fingernail infections, and three pulse treatments for toenail infections. Pulse treatments are always separated by a 3-week drug-free interval. Clinical response will become evident as the nail regrows, following discontinuation of the treatment.
Continuous Treatment: 2 caps daily (200 mg once daily) for 3 months.
Elimination of Sporanox from skin and nail tissue is slower than from plasma. Optimal clinical and mycological response is thus reached 2-4 weeks after the cessation of treatment for skin infections and 6-9 months after the cessation of treatment for nail infections.
Systemic Mycoses (Dosage recommendations vary according to the infection treated):
Aspergillosis: 200 mg once daily for 2-5 months.
Candidosis: 100-200 mg once daily for 3 weeks to 7 months.
For both aspergillosis and candidosis, increase dose to 200 mg twice daily in case of invasive or disseminated disease.
Non-Meningeal Cryptococcosis: 200 mg once daily for 2 months to 1 year.
Cryptococcal Meningitis: 200 mg twice daily for 2 months to 1 year.
Maintenance Therapy (Meningeal Cases): 200 mg once daily.
Histoplasmosis: 200 mg once daily or 200 mg twice daily for 8 months.
Sporotrichosis: 100 mg once daily for 3 months.
Paracoccidioidomycosis: 100 mg once daily for 6 months.
Chromomycosis: 100-200 mg once daily for 6 months.
Blastomycosis: 100 mg once daily or 200 mg twice daily for 6 months.