Should not be used in patients w/ type 1 DM. Risk of developing acute pancreatitis; symptomatic hypotension, particularly in patients w/ impaired renal function, elderly patients, patients on diuretics, or patients on antihypertensive therapy w/ history of hypotension; serious hypersensitivity reactions; bullous pemphigoid. Rare cases of diabetic ketoacidosis. Increase in cases of lower limb amputation (primarily of the toe). Should not be initiated in patients w/ eGFR <60 mL/min/1.73 m2
or CrCl <60 mL/min. Discontinue when eGFR is persistently <45 mL/min/1.73 m2
or CrCl persistently <45 mL/min. Increased risk of hypoglycaemia when used in combination w/ insulin &/or insulin secretagogue; genital mycotic infections; UTI; vol depletion in elderly patients. Patients w/ cardiac failure. Positive results for glucose in the urine. Not recommended to use 1,5-AG assay in monitoring glycaemic control. Should not be used during pregnancy & breast-feeding.