Increased risk of adverse reactions w/ aspirin; other NSAIDs including ibuprofen & cyclooxygenase-2 selective inhibitors. Enhanced effects of anticoagulants eg, warfarin. Increased risk of GI ulceration or bleeding w/ corticosteroids. Increased risk of GI bleeding w/ antiplatelet agents & SSRIs. Increased plasma levels of cardiac glycosides; lithium; methotrexate. Increased nephrotoxicity w/ ciclosporin; tacrolimus. Reduced effect of mifepristone. Increased risk of hematological toxicity w/ zidovudine. Increased risk of convulsions w/ quinolone antibiotics.