Sulconazole


Generic Medicine Info
Indications and Dosage
Topical/Cutaneous
Tinea corporis, Tinea cruris, Tinea versicolor
Adult: As 1% cream or solution: Apply a small amount and gently massage onto the affected and surrounding area(s) 1-2 times daily. Treatment duration: 3 weeks. Re-evaluate the diagnosis if significant clinical improvement does not occur after 4-6 weeks.

Topical/Cutaneous
Tinea pedis
Adult: As 1% cream: Apply a small amount and gently massage onto the affected and surrounding area(s) bid. Treatment duration: 4 weeks. Re-evaluate the diagnosis if significant clinical improvement does not occur after 4-6 weeks.
Contraindications
Hypersensitivity.
Special Precautions
Patient with hypersensitivity to other imidazole or triazole antifungal agents. The 1% topical solution is not indicated for the treatment of tinea pedis. Pregnancy and lactation.
Adverse Reactions
Significant: Skin irritation or sensitivity.
Skin and subcutaneous tissue disorders: Localised burning and stinging sensation, pruritus, erythema.
Patient Counseling Information
Avoid contact with eyes.
Action
Description:
Mechanism of Action: Sulconazole is an imidazole derivative synthetic antifungal agent. It inhibits the metabolic reactions necessary for the synthesis of ergosterol, thereby causing changes in membrane permeability and alterations in cell volume, secondary metabolic effects, and defective cell division and growth inhibition.
Pharmacokinetics:
Absorption: Absorbed percutaneously (approx 8.7-11%).
Excretion: Mainly via urine.
Chemical Structure

Chemical Structure Image
Sulconazole

Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 5318, Sulconazole. https://pubchem.ncbi.nlm.nih.gov/compound/5318. Accessed Aug. 26, 2022.

Storage
Store below 40°C. Protect the topical solution from light.
MIMS Class
Topical Antifungals & Antiparasites
ATC Classification
D01AC09 - sulconazole ; Belongs to the class of imidazole and triazole derivatives. Used in the topical treatment of fungal infection.
References
Anon. Sulconazole. AHFS Clinical Drug Information [online]. Bethesda, MD. American Society of Health-System Pharmacists, Inc. https://www.ahfscdi.com. Accessed 04/08/2022.

Anon. Sulconazole. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 04/08/2022.

Buckingham R (ed). Sulconazole Nitrate. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 04/08/2022.

Exelderm Cream (Journey Medical Corporation). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 04/08/2022.

Sulconazole Nitrate Solution (JG Pharma Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 04/08/2022.

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