One 14 mL or 20 mL vial of concentrate contains 840 mg or 1,200 mg atezolizumab*, respectively.
*Atezolizumab is an Fc-engineered, humanised IgG1 anti-programmed death-ligand 1 (PD-L1) monoclonal antibody produced in Chinese hamster ovary cells by recombinant DNA technology.
840 mg/14 mL: After dilution (see Special precautions for disposal and other handling under Cautions for Usage), one mL of solution contains approximately 3.2 mg of atezolizumab for the 840 mg dose and approximately 6.0 mg of atezolizumab for the 1680 mg dose.
1,200 mg/20 mL: After dilution (see Special precautions for disposal and other handling under Cautions for Usage), the final concentration of the diluted solution should be between 3.2 and 16.8 mg/mL.
Excipients/Inactive Ingredients: L-histidine, Glacial acetic acid, Sucrose, Polysorbate 20, Water for injections.