May precipitate abstinence effects in individuals on high doses of opioids. Increased sedative effect w/ alcohol. Potentiated resp depression w/ benzodiazepines, w/ risk of death. Increased CNS depression w/ other CNS depressants, other opioid derivatives (eg, analgesics & antitussives); certain antidepressants, sedative H1
-receptor antagonist, barbiturates, benzodiazepines, anxiolytics other than benzodiazepines, neuroleptics, clonidine & related substances. Possible exaggeration of the effects of opioids w/ MAOIs. Concomitant use w/ diazepam may lead to resp & CV collapses. Increased plasma conc w/ CYP3A4 inhibitors (eg, ketoconazole, gestodene, TAO, HIV PIs ritonavir, indinavir & saquinavir). May decrease plasma conc w/ CYP3A4 inducers (eg, phenobarb, carbamazepine, phenytoin, rifampicin). Tab
Concomitant use w/ phenoprocoumon may lead to purpura.