Firma Chun Cheong
Concise Prescribing Info
Timolol maleate
Treatment of elevated IOP in patients w/ ocular HTN or open-angle glaucoma.
Dosage/Direction for Use
1 drop in the affected eye(s) bd.
Hypersensitivity. Reactive airway disease (eg, bronchial asthma, history of bronchial asthma or severe COPD); sinus bradycardia; sick-sinus syndrome, SA block, 2nd or 3rd degree AV block not controlled w/ pace-maker; overt cardiac failure; cardiogenic shock.
Special Precautions
Not for inj or ingestion. Reports of severe resp & cardiac reactions. Patients w/ CV diseases & hypotension; 1st degree heart block; severe peripheral circulatory disturbance/disorders; cerebrovascular insufficiency; mild/moderate COPD; patients subject to spontaneous hypoglycaemia or w/ labile diabetes; corneal diseases; history of atopy or a history of severe anaphylactic reaction to a variety of allergens. May mask signs of hyperthyroidism & signs & symptoms of acute hypoglycaemia. May induce dryness of eyes. Muscle weakness. Choroidal detachment. Concomitant use w/ other systemic β-blocking agents or anaesth. May block systemic β-agonist effects of adrenaline. Contains benzalkonium Cl. Remove contact lenses before instillation, reinsert after 15 min. Temporary blurred vision or other visual disturbances may affect ability to drive or use machines. Pregnancy & lactation. Paed population.
Adverse Reactions
Vision blurred, eye pain, eye irritation (eg, burning sensation, irritating sensation, itching, tears, redness), ocular hyperaemia, ocular discomfort.
Drug Interactions
Mydriasis w/ adrenaline. Potential for additive effects resulting in hypotension &/or marked bradycardia w/ oral Ca channel blockers, β-adrenergic blocking agents, antiarrhythmics (including amiodarone), digitalis glycosides, parasympathomimetics, guanethidine, catecholamine-depleting drugs (eg, reserpine). Possible AV conduction disturbances, left ventricular failure, & hypotension w/ oral or IV Ca antagonists. Simultaneous use of β-adrenergic blocking agents & digitalis w/ diltiazem or verapamil may have an additive effect in prolonging AV conduction time. Potentiated systemic β-blockade w/ CYP2D6 inhibitors (eg, quinidine, fluoxetine, paroxetine). Enhanced rebound effect of HTN when stopping administration of clonidine. Blocked systemic effects of β-agonists (eg, adrenaline). Increased hypoglycaemic effect of insulin or oral antidiabetics. Monitor IOP when using w/ systemic or topical steroids. Use w/ caution when co-administered w/ psychotropic adrenergics.
ATC Classification
S01ED01 - timolol ; Belongs to the class of beta blocking agents. Used in the treatment of glaucoma.
Timolol Maleate Eye Drops 0.5% w/v
5 mL x 1's
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