Hypersensitivity to the active substances or to any of the excipients.
Hypersensitivity to aminoglycosides.
Herpes simplex keratitis.
Vaccinia, varicella, and other viral infection of cornea or conjunctiva (except herpes zoster keratitis).
Fungal diseases of ocular structures or untreated parasitic eye infections.
Mycobacterial ocular infections.
Infections or injuries limited to the superficial corneal epithelium.
TOBRADEX should not be used following an uncomplicated removal of a foreign body from the cornea.