No interaction studies have been performed. No clinically relevant interactions have been described with topical ocular dosing of TOBREX.
Concomitant and/or sequential use of an aminoglycoside (tobramycin) and other systemic, oral, or topical drugs that have neurotoxic, ototoxic, or nephrotoxic effects may result in additive toxicity and should be avoided, whenever possible.
Topical corticosteroids, when used in combination with tobramycin, may mask the clinical signs of bacterial, fungal, or viral infections and may suppress hypersensitivity reactions.
If more than one topical ophthalmic medicinal product is being used, the medicines must be administered at least 5 minutes apart. Eye ointments should be administered last.