Topamax

Topamax

topiramate

Manufacturer:

Janssen

Distributor:

DCH Auriga - Healthcare
/
Four Star
Concise Prescribing Info
Contents
Topiramate
Indications/Uses
Epilepsy: As monotherapy in patients w/ newly diagnosed epilepsy or for conversion to monotherapy in patients w/ epilepsy. As adjunctive therapy for adults & childn w/ partial onset seizures or generalized tonic-clonic seizures. Treatment of seizures associated w/ Lennox-Gastaut syndrome. Migraine: Prophylaxis of migraine headache.
Dosage/Direction for Use
Adjunctive therapy epilepsy Adult Initially 25-50 mg nightly for 1 wk. Subsequently, at wkly or bi-wkly intervals, the dose should be increased by 25-50 (to 100) mg/day & taken in 2 divided doses. Childn ≥2 yr 5-9 mg/kg/day in 2 divided doses. Titration should begin at 1-3 mg/kg/day nightly for the 1st wk, thereafter increased at 1-2 wk intervals by increments of 1-3 mg/kg/day given in 2 divided doses. Monotherapy epilepsy Adult Initially 25 mg nightly for 1 wk, thereafter increased at 1-2 wk intervals by increments of 25-50 mg/day, given in 2 divided doses. Recommended initial target dose: 100 mg/day, max daily dose: 500 mg. Childn ≥2 yr Initially 0.5-1 mg/kg nightly for the 1st wk, thereafter increased at 1-2 wk intervals by increments of 0.5-1 mg/kg/day, given in 2 divided doses. Recommended initial target dose: 3-6 mg/kg/day. Prophylaxis of migraine headache Initially 25 mg nightly for 1 wk increased at 25 mg/day increments at 1 wk intervals. Recommended total daily dose: 100 mg/day in 2 divided doses.
Administration
May be taken with or without food: Swallow whole, do not chew/crush.
Special Precautions
Gradual withdrawal. Renal or hepatic impairment, predisposition to nephrolithiasis. Acute myopia associated w/ secondary angle closure glaucoma. May impair ability to drive or operate machinery. Pregnancy & lactation.
Adverse Reactions
Somnolence, dizziness, nervousness, ataxia, fatigue, speech disorders/related speech problems, psychomotor slowing, abnormal vision, memory difficulty, confusion, paraesthesia, diplopia, anorexia, nystagmus, nausea, wt loss, language problems, difficulty w/ concentration/attention, depression, abdominal pain, asthenia & mood problems.
Drug Interactions
Phenytoin, carbamazepine, digoxin, OCs, metformin, agents predisposing to nephrolithiasis.
ATC Classification
N03AX11 - topiramate ; Belongs to the class of other antiepileptics.
Presentation/Packing
Form
Topamax tab 100 mg
Packing/Price
60's
Form
Topamax tab 25 mg
Packing/Price
60's
Form
Topamax tab 50 mg
Packing/Price
60's
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