Discontinue use in case of serious hypersensitivity reactions. Increased risk of infection. Evaluate for TB prior to treatment initiation. Monitor for signs & symptoms of active TB during & after treatment. Concurrent use w/ live vaccines. Withhold treatment for at least 12 wk after last dose prior to live viral or bacterial vaccination; treatment can be resumed 2 wk after vaccination. Women of childbearing potential should use effective methods of contraception during & for at least 12 wk after treatment. Pregnancy & lactation. Elderly ≥65 yr. Childn & adolescent <18 yr.