estradiol + norethisterone


Novo Nordisk


Firma Chun Cheong
Full Prescribing Info
Blue FC tab: Estradiol 2 mg. White FC tab: Estradiol 2 mg, norethisterone acetate 1 mg. Red FC tab: Estradiol 1 mg.
Each blue film-coated tablet contains estradiol 2 mg (as estradiol hemihydrate).
Each white film-coated tablet contains estradiol 2 mg (as estradiol hemihydrate) and norethisterone acetate 1 mg.
Each red film-coated tablet contains estradiol 1 mg (estradiol hemihydrate).
Excipient with known effect: Lactose monohydrate.
Excipients/Inactive Ingredients: Tablet Core: Lactose monohydrate, maize starch, hydroxypropylcellulose, talc and magnesium stearate.
Film-coating: Blue tablets: Hypromellose, talc, titanium dioxide (E171), indigo carmine (E132) and macrogol 400. White tablets: Hypromellose, triacetin and talc. Red tablets: Hypromellose, talc, titanium dioxide (E171), red iron oxide (E172) and propylene glycol.
Pharmacotherapeutic Group: Progestagens and oestrogens, sequential preparations. ATC Code: G03FB05.
Pharmacology: Pharmacodynamics: Estradiol: The active ingredient, synthetic 17β-estradiol, is chemically and biologically identical to endogenous human estradiol. It substitutes for the loss of oestrogen production in menopausal women and alleviates menopausal symptoms. Oestrogens prevent bone loss following menopause or ovariectomy.
Norethisterone Acetate: Synthetic progestagen with actions similar to those of progesterone, a natural female sex hormone. As oestrogens promote the growth of the endometrium, unopposed oestrogens increase the risk of endometrial hyperplasia and cancer. The addition of a progestagen reduces the oestrogen-induced risk of endometrial hyperplasia in non-hysterectomised women.
Relief of menopausal symptoms is achieved during the first few weeks of treatment.
Regular withdrawal bleeding occurred in 93% of the women with a mean duration of 3-4 days. Oestrogen deficiency at menopause is associated with an increased bone turnover and decline in bone mass. The effect of oestrogens on the bone mineral density is dose-dependent. Protection appears to be effective for as long as treatment is continued. After discontinuation of HRT, bone mass is lost at a rate similar to that in untreated women.
Evidence from the WHI trial and meta-analysis of trials show that current use of HRT, oestrogen alone or in combination with a progestagen-given to predominantly healthy women-reduces the risk of hip, vertebral and other osteoporotic fractures. HRT may also prevent fractures in women with low bone density and/or established osteoporosis, but the evidence for that is limited. Studies based on measurement of bone mineral content have shown that Trisequens is effective in the prevention of osteoporosis in postmenopausal women. After 2 years of treatment, bone mineral density in the spine had increased by 5.14% and in the hip by 3.21%.
Pharmacokinetics: Following oral administration of 17β-estradiol in micronised form, rapid absorption from the gastrointestinal tract occurs. It undergoes extensive first-pass metabolism in the liver and other enteric organs, and reaches a peak plasma concentration of approximately 44 pg/mL (range 30-53 pg/mL) within 6 hours after intake of 2 mg. The half-life of 17β-estradiol is about 18 hours. It circulates bound to SHBG (37%) and to albumin (61%), while only approximately 1-2% is unbound. Metabolism of 17β-estradiol occurs mainly in the liver and the gut but also in target organs, and involves the formation of less active or inactive metabolites, including oestrone, catecholoestrogens and several oestrogen sulfates and glucuronides. Oestrogens are excreted with the bile, hydrolysed and reabsorbed (enterohepatic circulation), and mainly eliminated in urine in biologically inactive form.
After oral administration, norethisterone acetate is rapidly absorbed and transformed to norethisterone (NET). It undergoes first-pass metabolism in the liver and other enteric organs, and reaches a peak plasma concentration of approximately 9 ng/mL (range 6-11 ng/mL) within 1 hour after intake of 1 mg. The terminal half-life of NET is about 10 hours. NET binds to SHBG (36%) and to albumin (61%).
The most important metabolites are isomers of 5α-dihydro-NET and of tetrahydro-NET, which are excreted mainly in the urine as sulfate or glucuronide conjugates.
The pharmacokinetics of estradiol is not influenced by norethisterone acetate.
The pharmacokinetic properties in the elderly have not been studied.
Toxicology: Preclinical Safety Data: The toxicity profiles of estradiol and norethisterone acetate are well-known. There are no preclinical data of relevance to the prescriber which are additional to that already included in other sections.
Hormone Replacement Therapy (HRT) for oestrogen deficiency symptoms in postmenopausal women with at least 6 months since last menses.
Prevention of osteoporosis in postmenopausal women at high risk of future fractures who are intolerant of, or contraindicated for, other medicinal products approved for the prevention of osteoporosis (see Precautions). The experience treating women older than 65 years is limited.
Dosage/Direction for Use
Trisequens is a continuous sequential HRT product. The oestrogen is dosed continuously. The progestagen is added for 10 days of every 28-day cycle, in a sequential manner.
One tablet should be taken orally once a day without interruption, preferably at the same time of the day starting with oestrogen therapy (blue film-coated tablet) over 12 days, followed by 10 days of oestrogen/progestagen therapy (white film-coated tablet) and 6 days of oestrogen therapy (red film-coated tablet). A regular shedding of the endometrium is usually induced during the red tablet phase.
After intake of the last red tablet, treatment is continued with the first blue tablet of a new pack on the next day.
In women who are not taking HRT or women in transition from a continuous combined HRT product, treatment with Trisequens may be started on any convenient day. In women in transition from another sequential HRT regimen, treatment should begin the day following completion of the preceding regimen. For initiation and continuation of treatment of postmenopausal symptoms, the lowest effective dose for the shortest duration (see Precautions) should be used.
If the patient has forgotten to take a tablet, the tablet should be taken as soon as possible within the next 12 hours. If more than 12 hours have passed, the tablet should be discarded. Forgetting a dose may increase the likelihood of breakthrough bleeding and spotting.
Overdose may be manifested by nausea and vomiting. Treatment should be symptomatic.
Known, past or suspected breast cancer; known, past or suspected oestrogen-dependent malignant tumours (e.g. endometrial cancer); undiagnosed genital bleeding; untreated endometrial hyperplasia; previous or current venous thromboembolism (deep venous thrombosis, pulmonary embolism); active or previous arterial thromboembolic disease (e.g. angina, myocardial infarction); known thrombophilic disorders (e.g. protein C, protein S or antithrombin deficiency (see Precautions)); acute liver disease or a history of liver disease as long as liver function tests have failed to return to normal; known hypersensitivity to the active substances or to any of the excipients; porphyria.
Special Precautions
For the treatment of postmenopausal symptoms, HRT should only be initiated for symptoms that adversely affect quality of life. In all cases, a careful appraisal of the risks and benefits should be undertaken at least annually and HRT should only be continued as long as the benefit outweighs the risk.
Evidence regarding the risks associated with HRT in the treatment of premature menopause is limited. Due to the low level of absolute risk in younger women, however, the balance of benefits and risks for these women may be more favourable than in older women.
Medical Examination/Follow-up: Before initiating or reinstituting HRT, a complete personal and family medical history should be taken. Physical (including pelvic and breast) examination should be guided by this and by the contraindications and warnings for use. During treatment, periodic check-ups are recommended of a frequency and nature adapted to the individual woman. Women should be advised what changes in their breasts should be reported to their doctor or nurse (see Breast Cancer as follows). Investigations, including appropriate imaging tools, e.g. mammography, should be carried out in accordance with currently accepted screening practices and modified to the clinical needs of the individual.
Conditions Which Need Supervision: If any of the following conditions are present, have occurred previously and/or have been aggravated during pregnancy or previous hormone treatment, the patient should be closely supervised. It should be taken into account that these conditions may recur or be aggravated during treatment with Trisequens, in particular: Leiomyoma (uterine fibroids) or endometriosis, risk factors for thromboembolic disorders (see as follows), risk factors for oestrogen-dependent tumours, e.g. 1st degree heredity for breast cancer, hypertension, liver disorders (e.g. liver adenoma), diabetes mellitus with or without vascular involvement, cholelithiasis, migraine or (severe) headache, systemic lupus erythematosus, a history of endometrial hyperplasia (see as follows), epilepsy, asthma, otosclerosis.
Reasons for Immediate Withdrawal of Therapy: Therapy should be discontinued in case a contraindication is discovered and in the following situations: Jaundice or deterioration in liver function, significant increase in blood pressure, new onset of migraine-type headache, pregnancy.
Endometrial Hyperplasia and Carcinoma: In women with an intact uterus, the risk of endometrial hyperplasia and carcinoma is increased when oestrogens are administered alone for prolonged periods. The reported increase in endometrial cancer risk among oestrogen-only users varies from 2 to 12-fold compared with non-users, depending on the duration of treatment and oestrogen dose (see Adverse Reactions). After stopping treatment, the risk may remain elevated for more than 10 years.
The addition of a progestagen cyclically for at least 10 days per month/28 day cycle or continuous combined oestrogen-progestagen therapy in non-hysterectomised women prevents the excess risk associated with oestrogen-only HRT. Breakthrough bleeding and spotting may occur during the first months of treatment. If breakthrough bleeding or spotting continues after the first months of treatment, appears after some time during therapy, or continues after treatment has been discontinued, the reason should be investigated, which may include endometrial biopsy to exclude endometrial malignancy.
Breast Cancer: The overall evidence suggests an increased risk of breast cancer in women taking combined oestrogen-progestagen and possibly also oestrogen-only HRT that is dependent on the duration of taking HRT.
The randomised placebo-controlled trial, the Women's Health Initiative study (WHI), and epidemiological studies are consistent in finding an increased risk of breast cancer in women taking combined oestrogen-progestagen HRT that becomes apparent after about 3 years (see Adverse Reactions).
The excess risk becomes apparent within a few years of use but returns to baseline within a few (at most 5) years after stopping treatment.
HRT, especially oestrogen-progestagen combined treatment, increases the density of mammographic images which may adversely affect the radiological detection of breast cancer.
Ovarian Cancer: Ovarian cancer is much rarer than breast cancer. Long-term (at least 5-10 years) use of oestrogen-only HRT products has been associated with a slightly increased risk of ovarian cancer (see Adverse Reactions). Some studies, including the WHI trial, suggest that the long-term use of combined HRT may confer a similar or slightly smaller risk (see Adverse Reactions).
Venous Thromboembolism: HRT is associated with a 1.3 to 3-fold risk of developing venous thromboembolism (VTE), i.e. deep vein thrombosis or pulmonary embolism. The occurrence of such an event is more likely in the first year of HRT than later (see Adverse Reactions).
Patients with known thrombophilic states have an increased risk of VTE and HRT may add to this risk. HRT is therefore contraindicated in these patients (see Contraindications).
Generally recognised risk factors for VTE include use of oestrogens, older age, major surgery, prolonged immobilisation, obesity (BMI >30 kg/m2), pregnancy/ postpartum period, systemic lupus erythematosus (SLE) and cancer. There is no consensus about the possible role of varicose veins in VTE.
As in all postoperative patients, prophylactic measures need to be considered to prevent VTE following surgery. If prolonged immobilisation is to follow elective surgery, temporarily stopping HRT 4 to 6 weeks earlier is recommended. Treatment should not be restarted until the woman is completely mobilised.
In women with no personal history of VTE but with a first degree relative with a history of VTE at a young age, screening may be offered after careful counselling regarding its limitations (only a proportion of thrombophilic defects are identified by screening). If a thrombophilic defect is identified which segregates with VTE in family members or if the defect is 'severe' (e.g. antithrombin, protein S or protein C deficiencies or a combination of defects), HRT is contraindicated.
Women already on chronic anticoagulant treatment require careful consideration of the benefit-risk of use of HRT. If VTE develops after initiating therapy, the drug should be discontinued. Patients should be told to contact their doctors immediately when they are aware of a potential thromboembolic symptom (e.g. painful swelling of a leg, sudden pain in the chest, dyspnoea).
Coronary Artery Disease (CAD): There is no evidence from randomised controlled trials of protection against myocardial infarction in women with or without existing CAD who received combined oestrogen-progestagen or oestrogen-only HRT. The relative risk of CAD during use of combined oestrogen-progestagen HRT is slightly increased. As the baseline absolute risk of CAD is strongly dependent on age, the number of extra cases of CAD due to oestrogen-progestagen use is very low in healthy women close to menopause but will rise with more advanced age.
Ischaemic Stroke: Combined oestrogen-progestagen and oestrogen-only therapy are associated with an up to 1.5-fold increase in risk of ischaemic stroke. The relative risk does not change with age or time since menopause. However, as the baseline risk of stroke is strongly age-dependent, the overall risk of stroke in women who use HRT will increase with age (see Adverse Reactions).
Other Conditions: Oestrogens may cause fluid retention, and therefore patients with cardiac or renal dysfunction should be carefully observed. Women with pre-existing hypertriglyceridaemia should be followed closely during oestrogen replacement or hormone replacement therapy, since rare cases of large increases of plasma triglycerides leading to pancreatitis have been reported with oestrogen therapy in this condition.
Oestrogens increase thyroid binding globulin (TBG), leading to increased circulating total thyroid hormone, as measured by protein-bound iodine (PBI), T4 levels (by column or by radioimmunoassay) or T3 levels (by radioimmunoassay). T3 resin uptake is decreased, reflecting the elevated TBG. Free T4 and free T3 concentrations are unaltered. Other binding proteins may be elevated in serum, i.e. corticoid binding globulin (CBG), sex-hormone-binding globulin (SHBG) leading to increased circulating corticosteroids and sex steroids, respectively. Free or biological active hormone concentrations are unchanged. Other plasma proteins may be increased (angiotensinogen/renin substrate, alpha-I-antitrypsin and ceruloplasmin).
HRT use does not improve cognitive function. There is some evidence of increased risk of probable dementia in women who start using continuous combined or oestrogen-only HRT after the age of 65.
Trisequens tablets contain lactose monohydrate. Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.
Effects on Ability to Drive and Use Machines: Trisequens has no known effect on the ability to drive or use machines.
Use In Pregnancy & Lactation
Use in Pregnancy: Trisequens is not indicated during pregnancy. If pregnancy occurs during medication with Trisequens, treatment should be withdrawn immediately.
Clinically, data on a limited number of exposed pregnancies indicate adverse effects of norethisterone on the foetus. At doses higher than normally used in OC and HRT formulations, masculinisation of female foetuses was observed.
The results of most epidemiological studies to date, relevant to inadvertent foetal exposure to combinations of oestrogens and progestagens, indicate no teratogenic or foetotoxic effect.
Use in Lactation: Trisequens is not indicated during lactation.
Adverse Reactions
Clinical Experience: The most frequently reported adverse events in the clinical trials with Trisequens were vaginal bleeding and breast pain/tenderness, reported in approximately 10% to 20% of patients. Vaginal bleeding usually occurred in the first months of treatment. Breast pain usually disappeared after a few months of therapy. All adverse events observed in the randomised clinical trials with a higher frequency in patients treated with Trisequens or similar HRT products as compared to placebo, and which on an overall judgement are possibly related to treatment are presented as follows:
Very common: ≥1/10: Reproductive System and Breast Disorders: Breast pain or breast tenderness, menstruation irregular or menorrhagia.
Common: ≥1/100; <1/10: Infections and Infestations: Genital candidiasis or vaginitis, see also Reproductive System and Breast Disorders.
Metabolism and Nutrition Disorders: Fluid retention, see also General Disorders and Administration Site Conditions.
Psychiatric Disorders: Depression or depression aggravated.
Nervous System Disorders: Headache, migraine or migraine aggravated.
Gastrointestinal Disorders: Nausea, abdominal pain, abdominal distension, abdominal discomfort.
Musculoskeletal, Connective Tissue and Bone Disorders: Back pain, leg cramps.
Reproductive System and Breast Disorders: Breast oedema or breast enlargement, uterine fibroids aggravated or uterine fibroids recurrence or uterine fibroids.
General Disorders and Administration Site Conditions: Oedema peripheral.
Investigations: Weight increased.
Uncommon: ≥1/1,000; <1/100: Immune System Disorders: Hypersensitivity, see also Skin and Subcutaneous Tissue Disorders.
Psychiatric Disorders: Nervousness.
Vascular Disorders: Thrombophlebitis superficial.
Gastrointestinal Disorders: Flatulence or bloating.
Skin and Subcutaneous Tissue Disorders: Alopecia, hirsutism or acne, pruritus or urticaria.
Reproductive System and Breast Disorders: Endometrial hyperplasia, dysmenorrhoea, see also back pain under Musculoskeletal, Connective Tissue and Bone Disorders and abdominal pain under Gastrointestinal Disorders.
General Disorders and Administration Site Conditions: Drug ineffective.
Rare: ≥1/10,000; <1/1,000: Vascular Disorders: Pulmonary embolism, thrombophlebitis deep.
Post-Marketing Experience: In addition to the above mentioned adverse drug reactions, those presented below have been spontaneously reported, and are by an overall judgement considered possibly related to Trisequens treatment. The reporting rate of these spontaneous adverse drug reactions is very rare (<1/10,000, not known (cannot be estimated from the available data)).
Post-marketing experience is subject to under reporting especially with regard to trivial and well-known adverse drug reactions. The presented frequencies should be interpreted in that light.
Neoplasms Benign and Malignant (including cysts and polyps): Endometrial cancer.
Immune System Disorders: Generalised hypersensitivity reactions (e.g. anaphylactic reaction/shock).
Psychiatric Disorders: Insomnia, anxiety, libido decreased, libido increased.
Nervous System Disorders: Dizziness, stroke.
Eye Disorders: Visual disturbances.
Cardiac Disorders: Myocardial infarction.
Vascular Disorders: Hypertension aggravated.
Gastrointestinal Disorders: Dyspepsia, vomiting.
Hepatobiliary Disorders: Gall bladder disease, cholelithiasis, cholelithiasis aggravated, cholelithiasis recurrence.
Skin and Subcutaneous Tissue Disorders: Seborrhoea, rash, angioneurotic oedema.
Reproductive System and Breast Disorders: Endometrial hyperplasia, vulvovaginal pruritus.
Investigations: Weight decreased, blood pressure increased.
Other adverse reactions have been reported in association with oestrogen/progestagen treatment.
Skin and Subcutaneous Disorders: Alopecia, chloasma, erythema multiforme, erythema nodosum, vascular purpura; Probable dementia over the age of 65 (see Precautions).
Breast Cancer Risk: An up to 2-fold increased risk of having breast cancer diagnosed is reported in women taking combined oestrogen-progestagen therapy for more than 5 years.
Any increased risk in users of oestrogen-only therapy is substantially lower than that seen in users of oestrogen-progestagen combinations. The level of risk is dependent on the duration of use (see Precautions).
Results of the largest randomised placebo-controlled trial (WHI study) and largest epidemiological study (MWS) are presented as follows:
Million Women Study-Estimated additional risk of breast cancer after 5 years' use oestrogen-only HRT:
Age range (years): 50-65.
Incidence per 1,000 never-users of HRT over 5 years*: 9-12.
Risk ratio**: 1.2.
Additional cases per 1,000 HRT users over 5 years' use (95% CI): 1-2 (0-3).
Combined oestrogen-progestagen: Age range (years): 50-65.
Incidence per 1,000 never-users of HRT over 5 years*: 9-12.
Risk ratio**: 1.7.
Additional cases per 1,000 HRT users over 5 years' use (95% CI): 6 (5-7).
*Taken from baseline incidence rates in developed countries.
**Overall risk ratio. The risk ratio is not constant but will increase with increasing duration on use.
Note: Since the background incidence of breast cancer differs by EU country, the number of additional cases of breast cancer will also change proportionately.
US WHI Studies-Additional risk of breast cancer after 5 years' use CEE oestrogen-only: Age range (years): 50-79.
Incidence per 1,000 women in placebo arm over 5 years: 21.
Risk ratio and 95% CI: 0.8 (0.7-1.0).
Additional cases per 1,000 HRT users over 5 years' use (95% CI): -4 (-6-0)*.
CEE+MPA oestrogen-progestagen**: Age range (years): 50-79.
Incidence per 1,000 women in placebo arm over 5 years: 17.
Risk ratio and 95% CI: 1.2 (1.0-1.5).
Additional cases per 1,000 HRT users over 5 years' use (95% CI): 4 (0-9).
*WHI study in women with no uterus, which did not show an increase in risk of breast cancer.
**When the analysis was restricted to women who had not used HRT prior to the study there was no increased risk apparent during the first 5 years of treatment. After 5 years the risk was higher than in non-users.
Endometrial Cancer Risk: The endometrial cancer risk is about 5 in every 1,000 women with a uterus not using HRT. In women with a uterus, use of oestrogen-only HRT is not recommended because it increases the risk of endometrial cancer (see Precautions). Depending on the duration of oestrogen-only use and oestrogen dose, the increase in risk of endometrial cancer in epidemiological studies varied from between 5 and 55 extra cases diagnosed in every 1,000 women between the ages of 50 and 65. Adding a progestagen to oestrogen-only therapy for at least 12 days per cycle can prevent this increased risk. In the Million Women Study, the use of 5 years of combined (sequential or continuous) HRT did not increase the risk of endometrial cancer [RR of 1.0 (0.8-1.2)].
Ovarian Cancer Risk: Long-term use of oestrogen-only and combined oestrogen-progestagen HRT has been associated with a slightly increased risk of ovarian cancer. In the Million Women Study, 5 years of HRT resulted in 1 extra case per 2,500 users.
Risk of Venous Thromboembolism: HRT is associated with a 1.3 to 3-fold increased relative risk of developing venous thromboembolism (VTE), i.e. deep vein thrombosis or pulmonary embolism. The occurrence of such an event is more likely in the first year of using HRT (see Precautions). Results of the WHI studies are presented as follows:
WHI Studies-Additional risk of VTE over 5 years' use oral oestrogen-only*: Age range (years): 50-59.
Incidence per 1,000 women in placebo arm over 5 years: 7.
Risk ratio and 95% CI: 1.2 (0.6-2.4).
Additional cases per 1,000 HRT users over 5 years' use (95% CI): 1 (-3-10).
Oral combined oestrogen-progestagen: Age range (years): 50-59.
Incidence per 1,000 women in placebo arm over 5 years: 4.
Risk ratio and 95% CI: 2.3 (1.2-4.3).
Additional cases per 1,000 HRT users over 5 years' use (95% CI): 5 (1-13).
*Study in women with no uterus.
Risk of Coronary Artery Disease: The risk of coronary artery disease is slightly increased in users of combined oestrogen-progestagen HRT over the age of 60 (see Precautions).
Risk of Ischaemic Stroke: The use of oestrogen-only and oestrogen-progestagen therapy is associated with an up to 1.5-fold increased relative risk of ischaemic stroke. The risk of haemorrhagic stroke is not increased during use of HRT.
This relative risk is not dependent on age or on duration of use, but the baseline risk is strongly age-dependent. The overall risk of stroke in women who use HRT will increase with age (see Precautions).
WHI Studies Combined-Additional risk of ischaemic stroke* over 5 years' use: Age range (years) 50-59.
Incidence per 1,000 women in placebo arm over 5 years: 8.
Risk ratio and 95% CI: 1.3 (1.1-1.6).
Additional cases per 1,000 HRT users over 5 years' use (95% CI): 3 (1-5).
*No differentiation was made between ischaemic and haemorrhagic stroke.
Drug Interactions
The metabolism of oestrogens and progestagens may be increased by concomitant use of substances known to induce drug-metabolising enzymes, specifically cytochrome P450 enzymes, such as anticonvulsants (e.g. phenobarbital, phenytoin, carbamazepine) and anti-infectives (e.g. rifampicin, rifabutin, nevirapine, efavirenz). Ritonavir, telaprevir and nelfinavir, although known as strong inhibitors, by contrast exhibit inducing properties when used concomitantly with steroid hormones. Herbal preparations containing St John's Wort (Hypericum perforatum) may induce the metabolism of oestrogens and progestagens.
Clinically, an increased metabolism of oestrogens and progestagens may lead to decreased effect and changes in the uterine bleeding profile. Drugs that inhibit the activity of hepatic microsomal drug metabolising enzymes, e.g. ketoconazole, may increase circulating levels of the active substances in Trisequens.
Concomitant administration of cyclosporine may cause increased blood levels of cyclosporine, creatinine and transaminases due to decreased metabolism of cyclosporine in the liver.
Caution For Usage
Incompatibilities: Not applicable.
Special Precautions for Disposal and Other Handling: No special requirements.
Store below 25°C. Protect from light. Do not refrigerate.
Patient Counseling Information
User Instructions: How to Use the Calendar Pack: Set the day reminder: Turn the inner disc to set the day of the week opposite the little plastic tab.
Take the first day's tablet: Break the plastic tab and tip out the first tablet.
Move the dial every day: On the next day, simply move the transparent dial clockwise 1 space as indicated by the arrow. Tip out the next tablet. Remember to take only 1 tablet once a day. The transparent dial can only be turned after the tablet in the opening has been removed.
ATC Classification
G03FB05 - norethisterone and estrogen ; Belongs to the class of progestogens and estrogens in sequential preparations.
FC tab (12 blue tablets: biconvex, engraved with NOVO 280, diameter 6 mm; 10 white tablets: biconvex, engraved with NOVO 281, diameter 6 mm; 6 red tablets: biconvex, engraved with NOVO 282, diameter 6 mm) x 28's.
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